Mouse Monoclonal MAP2K6 Antibody

The MAP2K6 antibody is a crucial tool for studying the mitogen-activated protein kinase kinase 6 (MAP2K6), also known as MEK6 or MKK6. a serine/threonine kinase within the MAPK signaling pathway. MAP2K6 functions as a dual-specificity kinase that directly phosphorylates and activates p38 MAPK (mitogen-activated protein kinase) in response to cellular stressors, cytokines, or inflammatory signals. This pathway regulates diverse cellular processes, including apoptosis, differentiation, immune responses, and adaptation to oxidative or osmotic stress. MAP2K6 antibodies are widely used in research to detect endogenous MAP2K6 protein levels, assess its activation state via phosphorylation (e.g., at Ser207/Thr211), or study its interaction with upstream regulators (e.g., MAP3Ks) and downstream effectors (e.g., p38). These antibodies are essential in elucidating MAP2K6's role in diseases such as cancer, neurodegenerative disorders, and chronic inflammation. Validation typically includes Western blotting, immunohistochemistry, or immunofluorescence, with specificity confirmed using knockout controls. Researchers also utilize MAP2K6 antibodies to explore tissue-specific expression patterns or pharmacodynamic responses to kinase inhibitors, aiding drug development targeting the p38 pathway.