Mouse Monoclonal BMPR2 Antibody

BMPR2 (bone morphogenetic protein receptor type 2) is a transmembrane serine/threonine kinase receptor belonging to the TGF-β superfamily. It plays a critical role in mediating cellular responses to bone morphogenetic proteins (BMPs), regulating processes like cell proliferation, differentiation, apoptosis, and vascular homeostasis. BMPR2 dysfunction, particularly through genetic mutations or reduced expression, is strongly linked to heritable pulmonary arterial hypertension (HPAH) and implicated in idiopathic PAH (IPAH). Approximately 70-80% of HPAH cases and 10-40% of IPAH cases involve BMPR2 abnormalities. Antibodies targeting BMPR2 are essential tools for studying its expression, localization, and signaling in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence to assess protein levels in tissues or cell models, particularly in pulmonary vasculature studies. Additionally, these antibodies aid in exploring mechanisms underlying PAH pathogenesis, including endothelial dysfunction and smooth muscle cell proliferation. Recent research also investigates BMPR2's role in cancer, fibrosis, and metabolic disorders, expanding the antibody's utility in translational research. Commercial BMPR2 antibodies are typically developed against specific epitopes in the extracellular ligand-binding domain or intracellular kinase domain, with validation across species like human, mouse, and rat. Their application supports diagnostic profiling and therapeutic development targeting BMPR2-related pathways.