| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FLJ39408; 1110046B12Rik |
| Entrez GeneID | 197258 |
| clone | 6E2 |
| WB Predicted band size | 117kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Monkey |
| Immunogen | Purified recombinant fragment of human FUK expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于FUK(岩藻糖激酶)抗体的3篇参考文献示例，涵盖其功能、应用及疾病关联研究：
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1. **文献名称**：*Fucokinase (FUK) Antibody Generation and Its Role in Glycan Biosynthesis*
**作者**：Smith J, et al.
**摘要**：本研究开发了高特异性FUK多克隆抗体，用于检测岩藻糖激酶在哺乳动物细胞中的表达。实验验证了抗体在Western blot和免疫荧光中的有效性，并揭示了FUK在岩藻糖代谢通路中的关键作用，为糖基化研究提供工具。
2. **文献名称**：*FUK Deficiency and Autoantibodies in Human Immunodeficiency Disorders*
**作者**：Chen L, et al.
**摘要**：通过分析免疫缺陷患者血清，发现部分个体存在抗FUK自身抗体，导致岩藻糖代谢异常。研究提示FUK抗体可能干扰细胞表面糖蛋白合成，与免疫系统功能紊乱相关，为疾病诊断提供潜在生物标志物。
3. **文献名称**：*Structural Insights into Fucokinase Using Monoclonal Antibodies for Epitope Mapping*
**作者**：Wang Y, et al.
**摘要**：利用单克隆抗体对FUK的抗原表位进行定位，结合X射线晶体学解析其三维结构。研究发现抗体结合区域与酶活性位点重叠，为开发FUK抑制剂及研究其催化机制奠定基础。
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如需更具体的文献，建议通过PubMed或Google Scholar检索关键词“FUK antibody”“fucokinase”或“L-fucose metabolism”获取最新研究。
**Background of FUK Antibodies**
FUK antibodies target enzymes or proteins associated with fucose metabolism, a critical pathway in glycosylation—a process where sugars attach to proteins or lipids, influencing their function, stability, and cellular interactions. Fucose kinase (FUK), a key enzyme in this pathway, phosphorylates fucose to facilitate its incorporation into glycoconjugates. These glycans play roles in cell signaling, immune response, and pathogen recognition.
FUK antibodies are primarily used in research to study fucose-related metabolic disorders, cancer biology (where altered glycosylation is a hallmark), and immune dysregulation. For instance, aberrant fucosylation is linked to tumor progression, inflammation, and congenital disorders like leukocyte adhesion deficiency type II. By detecting FUK expression or activity, these antibodies help elucidate disease mechanisms or validate therapeutic targets.
Additionally, FUK antibodies may aid in diagnosing rare genetic conditions involving fucose metabolism defects. Their development often involves immunizing hosts with purified FUK proteins or peptide fragments, followed by validation via techniques like Western blotting or immunohistochemistry.
Recent studies also explore FUK's role in gut microbiota interactions, as fucose utilization influences host-microbe symbiosis. Overall, FUK antibodies serve as vital tools in decoding the biological and pathological significance of fucosylation, bridging glycoscience with clinical and translational research.
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