| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SL-1; STMY; STR1; CHDS6; MMP-3; STMY1 |
| Entrez GeneID | 4314 |
| clone | 4F10 |
| WB Predicted band size | 54kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MMP3 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于MMP3抗体的参考文献示例(内容为模拟概括，建议通过学术数据库核实具体文献)：
1. **"Role of MMP-3 in Breast Cancer Metastasis: Insights from Immunohistochemical Analysis"**
*作者：Smith J, et al.*
**摘要**：本研究通过免疫组化(IHC)和Western blot技术，利用MMP3特异性抗体分析乳腺癌组织中MMP3的表达水平，发现其高表达与肿瘤转移和不良预后显著相关。
2. **"MMP-3 Modulation in Rheumatoid Arthritis: Antibody-Based Detection and Therapeutic Implications"**
*作者：Chen L, et al.*
**摘要**：通过ELISA和免疫荧光技术检测类风湿性关节炎患者滑膜组织中的MMP3水平，发现炎症因子(如IL-1β)显著上调MMP3表达，提示其作为治疗靶点的潜力。
3. **"MMP-3 Activity in Corneal Wound Healing: A Neutralizing Antibody Approach"**
*作者：Garcia R, et al.*
**摘要**：研究使用MMP3中和抗体阻断其在角膜损伤模型中的活性，证实MMP3过度表达会延缓上皮修复，为眼部疾病治疗提供新策略。
4. **"MMP-3 Expression in Atherosclerotic Plaques: A Comparative Immunohistochemical Study"**
*作者：Wang Y, et al.*
**摘要**：通过免疫组化比较动脉粥样硬化患者与健康人群血管组织中MMP3的分布，揭示其在斑块不稳定性和基质降解中的关键作用。
**注意**：以上文献信息为示例性质，实际引用时请通过PubMed、Web of Science等平台检索最新或特定研究方向的文献，并核对作者、标题及摘要准确性。
Matrix metalloproteinase 3 (MMP3), also known as stromelysin-1. is a zinc-dependent endopeptidase involved in extracellular matrix (ECM) remodeling by degrading components like collagen, proteoglycans, and fibronectin. It plays critical roles in physiological processes such as tissue repair and pathological conditions including cancer metastasis, osteoarthritis, and inflammatory diseases. MMP3 is secreted as an inactive zymogen (pro-MMP3) and activated proteolytically, regulating cellular signaling pathways and influencing cell proliferation, apoptosis, and angiogenesis.
MMP3 antibodies are essential tools for studying its expression, localization, and activity in diseases. They are used in techniques like Western blotting, immunohistochemistry, and ELISA to quantify MMP3 levels in tissues or biological fluids, aiding in disease diagnosis and mechanistic research. In cancer, elevated MMP3 correlates with tumor invasiveness and poor prognosis, making it a potential therapeutic target. Therapeutic MMP3 antibodies aim to inhibit its enzymatic activity or block interactions with substrates, though challenges like substrate redundancy and off-target effects limit clinical translation. Research also explores MMP3 antibodies as biomarkers for monitoring disease progression or treatment response in arthritis and fibrosis. Ongoing studies focus on enhancing antibody specificity and developing dual-function agents for improved therapeutic efficacy.
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