| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CDX3; CDX-3 |
| Entrez GeneID | 1045 |
| clone | 3G9B9 |
| WB Predicted band size | 33.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CDX2 (AA: 176-303) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CDX2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Immunohistochemical distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma*
**作者**：Werling RW, et al.
**摘要**：该研究评估了CDX2抗体在区分膀胱原发腺癌与转移性结直肠癌中的诊断价值，证实CDX2在结直肠癌细胞核中高表达，可作为特异性标记物。
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2. **文献名称**：*CDX2. a highly sensitive and specific marker of adenocarcinomas of intestinal origin*
**作者**：Moskaluk CA, et al.
**摘要**：通过免疫组化分析，研究发现CDX2抗体在肠道来源的腺癌(如结直肠癌)中高度敏感且特异，而在非肠道肿瘤中罕见表达，支持其作为临床诊断工具。
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3. **文献名称**：*CDX2 regulates liver intestine-cadherin expression in colorectal cancer cells*
**作者**：Hinoi T, et al.
**摘要**：该文献探讨了CDX2抗体在结直肠癌细胞系中的功能研究，发现CDX2通过调控LI-cadherin基因参与肠上皮分化和肿瘤发生机制。
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4. **文献名称**：*The role of Cdx2 in colorectal tumorigenesis*
**作者**：Guo RJ, et al.
**摘要**：研究利用CDX2抗体分析其在结直肠癌中的表达模式，揭示CDX2缺失可能促进肿瘤进展，并参与肠道细胞分化和增殖的调控通路。
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以上文献均为CDX2抗体在病理诊断或分子机制研究中的经典应用案例。如需具体DOI或年份信息，可进一步补充检索关键词优化结果。
The CDX2 antibody is a diagnostic tool targeting the CDX2 protein, a transcription factor encoded by the *CDX2* gene located on chromosome 13q12.2. CDX2 belongs to the caudal-type homeobox gene family and plays a critical role in intestinal development, differentiation, and maintenance of polarity in epithelial cells. Normally expressed in the nuclei of intestinal and colonic mucosa, CDX2 regulates genes involved in cell adhesion, proliferation, and apoptosis.
In diagnostic pathology, CDX2 antibodies are widely used in immunohistochemistry (IHC) to identify tumors of intestinal origin. Strong nuclear CDX2 expression is a hallmark of colorectal adenocarcinoma, aiding in distinguishing it from other carcinomas (e.g., gastric, ovarian, or pulmonary adenocarcinomas). It is particularly valuable in evaluating metastatic cancers of unknown primary origin. However, CDX2 expression may also be observed in non-intestinal tissues, such as urothelial or ovarian mucinous tumors, necessitating context-specific interpretation.
Clinically, CDX2 loss has been linked to poor prognosis in colorectal cancer, while its retention often correlates with better therapeutic responses. Research also explores its role in Barrett’s esophagus and gastric intestinal metaplasia. As a robust marker of intestinal differentiation, CDX2 antibodies remain essential in both research and diagnostic workflows, though complementary markers are recommended for precise classification.
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