| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BDB; BDB1; NTRKR2 |
| Entrez GeneID | 4920 |
| clone | 6F2D10 |
| WB Predicted band size | 104.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ROR2 (AA: 59-155) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ROR2抗体的3篇代表性文献(模拟示例，非真实文献)：
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1. **文献名称**：*ROR2 Antibody Targeting Inhibits Wnt5a-Driven Osteosarcoma Metastasis*
**作者**：Takahiro Nakamura et al.
**摘要**：研究开发了一种靶向ROR2胞外域的单克隆抗体，通过阻断Wnt5a信号通路，显著抑制骨肉瘤细胞迁移和小鼠模型中的肺转移，证实ROR2抗体在癌症治疗中的潜力。
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2. **文献名称**：*A Novel ROR2-Specific Antibody Reveals Its Role in Neural Crest Cell Development*
**作者**：Ying Zhang et al.
**摘要**：利用新型ROR2抗体进行免疫组化及功能实验，揭示ROR2在胚胎神经嵴细胞定向迁移中的关键作用，为先天性发育异常疾病机制提供新见解。
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3. **文献名称**：*ROR2 as a Biomarker in Triple-Negative Breast Cancer: Diagnostic Utility of a High-Affinity Antibody*
**作者**：Maria Lopez et al.
**摘要**：报道一种高亲和力ROR2抗体的开发，证实其在三阴性乳腺癌组织中的高特异性表达，可作为预后标志物和抗体偶联药物(ADC)的靶点。
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**备注**：以上为模拟示例，实际文献需通过PubMed或Web of Science等平台检索确认。
The ROR2 (Receptor tyrosine kinase-like orphan receptor 2) antibody is a research tool designed to detect and study the ROR2 protein, a member of the receptor tyrosine kinase (RTK) family. ROR2 plays critical roles in developmental processes, particularly in skeletal formation, cell polarity, and tissue morphogenesis, by mediating non-canonical Wnt signaling pathways (e.g., Wnt5a). Dysregulation of ROR2 is linked to genetic disorders such as Robinow syndrome and brachydactyly type B, as well as cancer progression, including metastasis in breast cancer, melanoma, and osteosarcoma.
ROR2 antibodies are widely used in research to investigate protein expression, localization, and function in cellular and disease models. They enable techniques like Western blotting, immunohistochemistry, and flow cytometry. In therapeutic contexts, ROR2 is explored as a potential target for antibody-drug conjugates (ADCs) or inhibitors to block oncogenic signaling. Recent studies highlight its role in tumor microenvironments and drug resistance, driving interest in ROR2-targeted therapies.
Commercial ROR2 antibodies vary in specificity, with validation required for cross-reactivity and batch consistency. Challenges remain in distinguishing ROR2 isoforms and optimizing detection in complex tissues. Ongoing research aims to clarify its dual roles as both a tumor suppressor and promoter, depending on cellular context, underscoring the importance of reliable antibodies in advancing ROR2-related biomedical discoveries.
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