Mouse Monoclonal CCNE1 Antibody

The CCNE1 antibody is a crucial tool for detecting Cyclin E1. a protein encoded by the *CCNE1* gene that regulates the G1-to-S phase transition in the cell cycle. Cyclin E1 forms a complex with cyclin-dependent kinase 2 (CDK2), driving cell cycle progression by phosphorylating substrates essential for DNA replication. Overexpression of CCNE1 is linked to uncontrolled cell proliferation, genomic instability, and tumorigenesis, making it a biomarker in cancers like ovarian, breast, and endometrial carcinomas. The CCNE1 antibody is widely used in research to assess protein expression levels via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. It helps elucidate mechanisms of cell cycle dysregulation, evaluate cancer prognosis, and explore therapeutic strategies targeting Cyclin E1/CDK2. Studies also associate CCNE1 amplification with chemotherapy resistance, highlighting its clinical relevance. Researchers rely on validated CCNE1 antibodies to ensure specificity and reproducibility in both diagnostic and experimental settings, aiding advancements in oncology and molecular biology.