关键信息
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基因名
CD300a/LMIR1
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简介
CD300a/LMIR1 Protein, an inhibitory receptor, potentially diminishes cytolytic activity in NK cells and suppresses mast cell degranulation. It serves as a negative regulator in MYD88-mediated TLR signaling, activating PTPN6 but not TRIF. Upon tyrosine phosphorylation, CD300a/LMIR1 engages with PTN6/SHP-1, PTPN11/SHP-2, and INPP5D, showcasing its multifaceted involvement in immune regulation and cellular responses. CD300a/LMIR1 Protein, Human (HEK293, Fc-His) is the recombinant human-derived CD300a/LMIR1 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.
- 应用
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别名
CMRF35-like molecule 8; CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor
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种属
Human
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表达系统
HEK293
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标签
C-hFc;C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UGN4-1
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表达区间
L18-Q178
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蛋白长度
Extracellular Domain
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分子量
60-75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD300a, also known as LMIR1 (Leukocyte Immunoglobulin-Like Receptor 1), is an immune receptor belonging to the CD300 family, which plays a critical role in the regulation of immune responses. The study of CD300a/LMIR1 has gained significant attention due to its involvement in modulating the activity of various immune cells, including T cells, dendritic cells, and macrophages. This receptor has been shown to interact with phosphatidylserine and other ligands, leading to the suppression of inflammatory responses and promotion of immune tolerance. Research has indicated that CD300a can influence the development and function of regulatory T cells, thereby impacting the balance between immune activation and inhibition. Given its potential implications in autoimmune diseases, cancer, and transplantation, CD300a/LMIR1 is considered a promising target for therapeutic intervention. The generation and characterization of recombinant CD300a proteins provide valuable tools for understanding the receptor’s functional mechanisms and exploring its role in immune regulation. Studying these proteins can pave the way for the development of novel strategies to modulate immune responses in various clinical settings, enhancing our ability to treat immune-related disorders effectively.
