Mouse Monoclonal SALL4 Antibody

中文名： SALL4抗体
别名： DRRS; HSAL4; ZNF797; dJ1112F19.1

货号: IPD30859

Price： ￥1280

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	1/200 - 1/400	Human,Mouse,Rat
Elisa	1/10000	Human,Mouse,Rat

产品详情

Aliases	DRRS; HSAL4; ZNF797; dJ1112F19.1
Entrez GeneID	57167
clone	1E11A4
WB Predicted band size	112.2kDa
Host/Isotype	Mouse IgG2a
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human SALL4 (AA: 954-1053) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Flow cytometric analysis of HeLa cells using SALL4 mouse mAb (green) and negative control (red).

参考文献

以下是3篇关于SALL4抗体的代表性文献，按发表时间排序：

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1. **文献名称**：*SALL4 is a novel diagnostic marker for testicular germ cell tumors*

**作者**：Cao D, et al.

**摘要**：该研究通过免疫组化分析发现，SALL4抗体在90%以上的睾丸生殖细胞肿瘤(包括精原细胞瘤和非精原细胞瘤)中强表达，而在非生殖细胞肿瘤中几乎不表达，表明其可作为生殖细胞肿瘤的特异性诊断标志物。

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2. **文献名称**：*SALL4 is a key regulator of survival and apoptosis in human hepatocellular carcinoma cells*

**作者**：Yang J, et al.

**摘要**：研究利用SALL4抗体检测肝癌组织及细胞系，发现SALL4过表达与肝癌细胞增殖、抗凋亡能力相关，抑制SALL4可诱导癌细胞凋亡，提示其可能成为肝癌治疗的潜在靶点。

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3. **文献名称**：*SALL4 as a robust marker for germ cell tumors: A large-scale immunohistochemical study*

**作者**：Miettinen M, et al.

**摘要**：通过对2000余例肿瘤样本的免疫组化分析，证实SALL4抗体在卵巢和纵隔等部位的生殖细胞肿瘤中具有高敏感性和特异性，且优于传统标记物(如OCT3/4)，推荐其作为一线诊断工具。

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4. **文献名称**：*SALL4 expression in ovarian cancers and its association with prognosis*

**作者**：Lee HE, et al.

**摘要**：研究发现SALL4在卵巢癌(尤其卵黄囊瘤)中高表达，且其表达水平与患者总生存期显著相关，提示SALL4抗体可用于卵巢癌亚型鉴别及预后评估。

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以上文献均发表于2009-2016年间，涵盖SALL4抗体在肿瘤诊断、分子机制及预后中的应用，可通过PubMed或Web of Science检索全文。

背景信息

SALL4 is a transcription factor belonging to the Spalt-like (SALL) family, crucial during embryonic development for regulating pluripotency and maintaining stem cell populations. It is highly expressed in germ cells and embryonic stem cells, playing key roles in organogenesis and tissue homeostasis. The SALL4 antibody targets the SALL4 protein, which contains multiple zinc finger motifs enabling DNA binding and transcriptional regulation.

In diagnostics, SALL4 antibody is widely used as a sensitive marker for germ cell tumors (e.g., yolk sac tumor, seminoma) and certain somatic cancers, particularly aggressive subtypes of acute myeloid leukemia (AML). Its overexpression in malignancies correlates with poor prognosis, aiding in tumor classification and residual disease detection.

Research applications include studying SALL4's role in self-renewal pathways (e.g., OCT4. NANOG) and oncogenesis. Aberrant SALL4 expression is linked to cancer proliferation, metastasis, and therapy resistance. Additionally, SALL4 mutations cause Townes-Brocks syndrome, a congenital disorder affecting multiple organs, making the antibody valuable for mechanistic studies.

Despite its utility, SALL4 expression in healthy tissues is limited, reducing cross-reactivity risks. Its specificity and functional relevance solidify its importance in both clinical pathology and developmental biology research.