Mouse Monoclonal TH Antibody

Tyrosine hydroxylase (TH) antibodies are immunological tools primarily used to detect and study the enzyme tyrosine hydroxylase, a rate-limiting catalyst in the synthesis of catecholamines such as dopamine, norepinephrine, and epinephrine. TH is highly expressed in dopaminergic neurons of the substantia nigra, adrenal medulla, and sympathetic neurons, making it a critical biomarker for these cell types. In research, TH antibodies are widely employed in techniques like immunohistochemistry and Western blot to map catecholaminergic pathways, assess neuronal integrity in neurodegenerative models (e.g., Parkinson’s disease), and investigate neurodevelopmental or psychiatric disorders linked to dopamine dysregulation. Clinically, TH antibodies have gained attention in autoimmune contexts. Rare cases of autoimmune autonomic neuropathies or encephalitis involve autoantibodies targeting TH, potentially disrupting sympathetic or adrenomedullary function. Additionally, TH antibody levels are sometimes measured to evaluate sympathetic activity in conditions like hypertension or heart failure. Their specificity and utility in both basic and translational research underscore their importance in understanding catecholamine-related physiology and pathology. However, interpretation requires caution, as TH expression varies across tissues and may be influenced by stressors or pharmacological interventions.