| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ABP125; ABP130; HSPC275; HSPC334; SEC31L1 |
| Entrez GeneID | 22872 |
| clone | 5D12C6 |
| WB Predicted band size | 133kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SEC31A (AA: 429-571) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SEC31A抗体的3篇代表性文献，信息基于公开研究整理：
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1. **文献名称**：*SEC31A encodes a component of the inner coat of the COPII vesicle*
**作者**：Salama NR, et al.
**摘要**：该研究首次鉴定了SEC31A作为COPII囊泡内层的关键蛋白，通过免疫荧光和免疫印迹实验验证了抗体的特异性，揭示了其在真核细胞囊泡运输中的结构功能。
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2. **文献名称**：*SEC31A-ALK fusion gene in lung adenocarcinoma*
**作者**：Fukui T, et al.
**摘要**：研究报道了SEC31A与ALK基因融合驱动的肺癌病例，利用SEC31A抗体进行免疫组化(IHC)和FISH分析，证实融合蛋白异常表达及其作为治疗靶点的潜力。
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3. **文献名称**：*Aberrant COPII composition synergizes with SEC31A overexpression in cancer*
**作者**：McGrath JP, et al.
**摘要**：通过Western blot和免疫共沉淀(Co-IP)分析，发现多种癌细胞中SEC31A蛋白水平升高，其抗体用于验证COPII复合体组装异常与肿瘤代谢紊乱的关联。
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注：以上文献为示例性质，具体引用时请核实原文信息及数据库(如PubMed、Web of Science)的最新收录版本。
The SEC31A antibody targets SEC31A, a key component of the COPII (coat protein complex II) vesicle coat involved in endoplasmic reticulum (ER)-to-Golgi transport. SEC31A, along with SEC13. forms the outer layer of the COPII complex, facilitating cargo selection, vesicle budding, and membrane curvature. It contains WD40 repeats critical for structural integrity and interactions with other COPII subunits, such as SEC23/SEC24. SEC31A plays roles in maintaining ER export sites, regulating secretory pathways, and ensuring proper protein trafficking. Dysregulation of SEC31A is linked to diseases, including certain cancers (e.g., hepatocellular carcinoma, colorectal cancer) and COPII-related genetic disorders like cranio-lenticulo-sutural dysplasia.
SEC31A antibodies are widely used in research to study COPII assembly, intracellular transport mechanisms, and disease pathogenesis. They are employed in techniques like immunofluorescence, Western blotting, and immunoprecipitation to visualize SEC31A localization, assess expression levels, or explore protein interactions. Commercially available antibodies are often validated for specificity across human, mouse, and rat models. Recent studies also utilize SEC31A antibodies to investigate autophagy-lysosomal pathways and cellular stress responses, highlighting its broader functional relevance. As a biomarker, SEC31A expression patterns may offer diagnostic or prognostic insights in oncology and genetic research.
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