Mouse Monoclonal Rab6b Antibody

The Rab6b antibody is a crucial tool for studying the Rab6b protein, a member of the Rab GTPase family involved in regulating intracellular vesicle trafficking. Rab6b, a paralog of Rab6a, is primarily associated with retrograde transport from the Golgi apparatus to the endoplasmic reticulum (ER) and plays roles in Golgi organization, secretion, and autophagy. Unlike ubiquitously expressed Rab6a, Rab6b shows tissue-specific enrichment, particularly in the brain, suggesting specialized functions in neuronal cells. The Rab6b antibody enables researchers to detect and localize endogenous Rab6b protein in various experimental models, including Western blotting, immunofluorescence, and immunohistochemistry. It is widely used to investigate Rab6b's expression patterns, subcellular distribution, and interactions with effector proteins like BICD2 or dynein motor complexes. Due to Rab6b's implication in neurological disorders and cancer progression, this antibody also supports pathophysiological studies. Validating antibody specificity through knockout controls or siRNA knockdown is critical, as Rab6b shares significant homology with Rab6a. Commercial Rab6b antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Recent studies employing these antibodies have advanced our understanding of Rab6b's role in regulating secretory pathways, maintaining Golgi integrity, and modulating cellular stress responses.