| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CKR3; CCR3; CMKBR3; CC-CKR-3 |
| Entrez GeneID | 1232 |
| clone | 8E9H10 |
| WB Predicted band size | 41kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD193 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CD193(CCR3)抗体的代表性文献摘要：
1. **文献名称**: "Targeting CCR3 with Antibodies Reduces Eosinophilic Airway Inflammation in Asthma Models"
**作者**: Smith A, et al.
**摘要**: 研究开发了一种靶向CCR3的单克隆抗体，通过抑制嗜酸性粒细胞向肺部的迁移，显著减轻了小鼠哮喘模型的气道炎症，为过敏性疾病的治疗提供了潜在策略。
2. **文献名称**: "CCR3-Specific Antibody-Drug Conjugates for T-Cell Lymphoma Therapy"
**作者**: Lee J, et al.
**摘要**: 该文献报道了一种CCR3抗体-药物偶联物(ADC)，通过靶向表达CCR3的淋巴瘤细胞递送细胞毒素，在体外和动物模型中显示出选择性杀伤作用，提示其在T细胞淋巴瘤治疗中的潜力。
3. **文献名称**: "Structural Characterization of a Humanized Anti-CCR3 Antibody for Allergic Disease"
**作者**: Zhang Y, et al.
**摘要**: 研究通过人源化改造小鼠源CCR3抗体，解析了其与CCR3的复合物晶体结构，揭示了抗体阻断趋化因子结合的分子机制，为优化治疗性抗体设计提供了结构基础。
注：以上为示例性内容，实际文献需通过PubMed/Google Scholar等平台检索关键词“CCR3 antibody”或结合具体研究方向细化查询。
CD193. also known as CCR5 (C-C chemokine receptor type 5), is a G protein-coupled receptor expressed on immune cells, including T lymphocytes, macrophages, and dendritic cells. It binds chemokines such as CCL3. CCL4. and CCL5. playing a key role in leukocyte migration and inflammatory responses. CCR5 gained prominence due to its role as a co-receptor for HIV-1 entry into host cells, making it a critical target in HIV research. The discovery that individuals with a natural CCR5Δ32 mutation exhibit resistance to HIV infection spurred therapeutic strategies, including the development of CCR5 antagonists like maraviroc and gene-editing approaches (e.g., CRISPR-based CCR5 knockout).
CD193 antibodies are essential tools for studying CCR5 expression, function, and regulation. They enable applications like flow cytometry, immunohistochemistry, and blocking receptor-ligand interactions in vitro. Beyond HIV, CCR5 is implicated in autoimmune diseases, cancer metastasis, and inflammatory conditions (e.g., rheumatoid arthritis), driving interest in anti-CCR5 therapies. Monoclonal antibodies targeting CCR5 are being explored for modulating immune responses or inhibiting pathological cell migration. However, challenges remain in balancing therapeutic efficacy with potential off-target effects, given CCR5's physiological roles in immune surveillance. Research continues to refine CCR5-targeted biologics and small molecules for precision medicine applications.
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