| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | LAMPB; LAMP2; LAMP-2; LGP-96; LGP110 |
| Entrez GeneID | 3920 |
| clone | 6A10H10 |
| WB Predicted band size | 45kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD107b (AA: extra 29-168) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与CD107b(LAMP2)抗体相关的代表性文献，供参考：
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1. **文献名称**：*Lysosome-associated membrane proteins h-LAMP1 and h-LAMP2 are transcriptional targets of p53*
**作者**：Yasuda Y, et al.
**摘要**：研究发现p53蛋白通过调控h-LAMP1和h-LAMP2(CD107b)的表达影响溶酶体膜稳定性，CD107b抗体用于验证溶酶体膜蛋白在肿瘤细胞凋亡中的作用。
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2. **文献名称**：*Surface expression of lysosome-associated membrane protein-2 (CD107b) correlates with NK cell cytotoxicity*
**作者**：Alter G, et al.
**摘要**：利用CD107b抗体检测自然杀伤细胞(NK细胞)表面CD107b的表达，证明其可作为脱颗粒的标记物，与细胞毒性功能正相关。
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3. **文献名称**：*LAMP2 deficiency attenuates neurodegeneration in Parkinson’s disease model*
**作者**：Rothaug M, et al.
**摘要**：通过CD107b抗体标记溶酶体膜蛋白，研究LAMP2缺失对帕金森病模型中α-突触核蛋白清除的影响，揭示溶酶体功能障碍与神经退行性疾病的关联。
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**注**：CD107b是LAMP2的别称，以上文献可通过PubMed或Sci-Hub获取全文。如需更具体领域的研究，建议补充关键词(如免疫治疗、溶酶体功能等)。
CD107b, also known as lysosome-associated membrane protein-1 (LAMP-1), is a transmembrane glycoprotein predominantly localized in lysosomes and late endosomes. It belongs to the LAMP family, which plays critical roles in maintaining lysosomal integrity, regulating autophagy, and facilitating vesicular trafficking. CD107b is a heavily glycosylated protein with a molecular weight of approximately 110-120 kDa, characterized by a luminal domain with conserved N-linked glycosylation sites and a short cytoplasmic tail. Its expression on the plasma membrane increases during cellular activation or stress, particularly in immune cells like cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, where it serves as a marker of degranulation.
Antibodies targeting CD107b are widely used in flow cytometry and immunofluorescence to study lysosomal exocytosis, immune cell functionality, and cellular responses to pathogens or tumors. In research, surface CD107b detection helps quantify the release of lytic granules during immune responses, correlating with cytotoxic activity. Additionally, CD107b antibodies aid in investigating lysosomal disorders, neurodegenerative diseases, and cancer biology, as altered LAMP-1 expression is linked to tumor progression, metastasis, and immune evasion. Its role in cell adhesion and phagosome-lysosome fusion further underscores its relevance in infectious disease studies. CD107b antibodies thus serve as essential tools for exploring lysosomal dynamics, immune mechanisms, and disease pathogenesis.
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