Mouse Monoclonal KMT2C Antibody

The KMT2C antibody is a research tool designed to detect the KMT2C protein, a key epigenetic regulator belonging to the lysine methyltransferase family. KMT2C (lysine methyltransferase 2C), also known as MLL3. is part of the COMPASS-like complex that catalyzes histone H3 lysine 4 (H3K4) methylation, a modification associated with active gene transcription. Structurally, KMT2C contains multiple functional domains, including N-terminal DNA-binding motifs, a catalytic SET domain, and C-terminal regions involved in protein interactions. It plays critical roles in embryonic development, cell differentiation, and tumor suppression by modulating chromatin structure and gene expression. Dysregulation of KMT2C is linked to cancers (e.g., breast, lung, and colorectal cancers) and neurodevelopmental disorders like Kleefstra syndrome. The KMT2C antibody is widely used in techniques such as Western blotting, immunohistochemistry, and ChIP-seq to study its expression, localization, and molecular interactions. Researchers also employ it to explore KMT2C's involvement in disease mechanisms or therapeutic responses, particularly in oncology. Validating antibody specificity is crucial due to structural similarities with other KMT2 family members (e.g., KMT2A/B/D). As interest in epigenetic therapies grows, KMT2C remains a focal point for understanding chromatin dynamics and identifying biomarkers or drug targets.