| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | AGP2; AGP-B; AGP-B' |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ORM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ORM2抗体的3篇代表性文献，简要整理供参考：
1. **《ORM2 as a potential biomarker for non-small cell lung cancer》**
*作者：Li Y, et al. (2020)*
摘要：研究发现ORM2在非小细胞肺癌患者血清中显著高表达，其抗体检测可作为辅助诊断标志物，并提示与肿瘤微环境中的免疫抑制相关。
2. **《Anti-inflammatory role of ORM2 in modulating macrophage polarization》**
*作者：Park JH, et al. (2019)*
摘要：通过ORM2抗体阻断实验，证明ORM2通过调控巨噬细胞向M2型极化减轻炎症反应，为治疗慢性炎症疾病提供新靶点。
3. **《Serum ORM2 level correlates with insulin resistance in type 2 diabetes》**
*作者：Zhang Q, et al. (2021)*
摘要：利用ORM2特异性抗体检测发现，2型糖尿病患者血清ORM2水平与胰岛素抵抗指数正相关，提示其在代谢紊乱中的潜在作用。
**注**：以上文献为示例性内容，实际研究请通过PubMed或Web of Science以“ORM2 antibody”为关键词检索最新论文。
The ORM2 antibody targets the Orosomucoid 2 (ORM2) protein, a member of the acute-phase protein family predominantly synthesized in the liver. ORM2. also known as alpha-1-acid glycoprotein 2 (AGP2), is a glycosylated protein with immunomodulatory functions. Its expression is upregulated during inflammation, infection, or tissue injury, primarily in response to cytokines like interleukin-6 (IL-6) and interleukin-1 (IL-1). ORM2 plays roles in modulating immune responses, such as regulating neutrophil migration, influencing cell adhesion, and binding to drugs or endogenous compounds, thereby affecting their pharmacokinetics.
The ORM2 antibody is a critical tool for detecting and quantifying ORM2 in research and diagnostics. It is widely used in techniques like ELISA, Western blotting, and immunohistochemistry to study ORM2’s involvement in inflammatory diseases (e.g., sepsis, rheumatoid arthritis), cancer progression, and metabolic disorders. Elevated ORM2 levels are observed in conditions like hepatocellular carcinoma and chronic inflammation, suggesting its potential as a biomarker. Researchers also employ ORM2 antibodies to explore its interaction with pathogens or therapeutic agents, aiding in understanding disease mechanisms and drug development. Commercial ORM2 antibodies are typically validated for specificity and sensitivity to ensure reliable detection across biological samples.
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