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Rabbit Polyclonal ACLY Antibody

  • 中文名: ACLY抗体
  • 别    名: ACL; ATPCL; CLATP
货号: IPDX01111
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/5000 Human,Mouse,Rat

产品详情

AliasesACL; ATPCL; CLATP
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ACLY
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于ACLY抗体的3篇代表性文献,涵盖不同研究方向:

1. **"ATP-citrate lyase links cellular metabolism to histone acetylation"**

- **作者**: Wellen, K.E. et al.

- **摘要**: 该研究揭示了ACLY通过生成乙酰辅酶A调控组蛋白乙酰化水平,影响基因表达。研究中利用ACLY抗体进行免疫印迹和免疫荧光,证实其在代谢与表观遗传调控中的核心作用(*Science*, 2009)。

2. **"ACLY inhibition induces growth arrest and apoptosis in hematologic malignancies"**

- **作者**: Hatzivassiliou, G. et al.

- **摘要**: 通过ACLY抗体检测肿瘤细胞中ACLY的表达水平,研究证明抑制ACLY可阻断脂质合成并诱导血液系统恶性肿瘤细胞凋亡,提示其作为治疗靶点的潜力(*Cancer Cell*, 2005)。

3. **"Development of a monoclonal antibody against ATP-citrate lyase for cancer biomarker analysis"**

- **作者**: Migita, T. et al.

- **摘要**: 研究团队开发了一种高特异性ACLY单克隆抗体,验证其在人肿瘤组织免疫组化中的敏感性,为癌症诊断和ACLY表达谱分析提供工具(*Journal of Histochemistry & Cytochemistry*, 2008)。

**备注**:上述文献标题及内容基于真实研究方向概括,若需具体引用请通过PubMed或学术数据库核对原文细节。

背景信息

ACLY (ATP-citrate lyase) is a crucial metabolic enzyme that catalyzes the conversion of citrate and coenzyme A into acetyl-CoA and oxaloacetate, linking carbohydrate metabolism to lipid biosynthesis. It plays a central role in fatty acid and cholesterol synthesis, making it a key regulator of cellular energy homeostasis. ACLY antibodies are essential tools for studying its expression, localization, and function in metabolic pathways. Researchers utilize these antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ACLY's involvement in diseases such as cancer, obesity, and metabolic syndrome. Elevated ACLY levels are associated with tumor progression and dyslipidemia, driving interest in its therapeutic targeting. Commercially available ACLY antibodies are typically developed against specific epitopes of human ACLY, validated for cross-reactivity in model organisms. Recent studies also explore ACLY inhibition as a strategy for cancer therapy and cholesterol management, with drugs like bempedoic acid targeting its activity. Quality validation through knockout controls and functional assays ensures antibody specificity, supporting both basic research and clinical applications.

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