| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | S11 |
| WB Predicted band size | 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RPS11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RPS11抗体的3篇示例参考文献(内容为模拟示例，实际文献请通过学术数据库查询)：
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1. **标题**：*RPS11 Antibody Characterization in Diamond-Blackfan Anemia Diagnosis*
**作者**：Smith A, et al.
**摘要**：研究验证了一种高特异性RPS11多克隆抗体在诊断Diamond-Blackfan贫血(DBA)中的应用，发现部分DBA患者存在RPS11基因突变，抗体可用于骨髓细胞中RPS11蛋白表达的定量检测。
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2. **标题**：*Development of a Monoclonal Antibody Against RPS11 for Cancer Biomarker Studies*
**作者**：Chen L, et al.
**摘要**：报道了一种新型RPS11单克隆抗体的开发，该抗体在乳腺癌组织样本中表现出高亲和力，证实RPS11在肿瘤细胞中异常高表达，提示其作为潜在癌症生物标志物的可能性。
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3. **标题**：*RPS11 Autoantibodies in Autoimmune Diseases: A Proteomic Approach*
**作者**：Wang Y, et al.
**摘要**：通过蛋白质组学筛选发现，系统性红斑狼疮(SLE)患者血清中RPS11自身抗体水平显著升高，提示RPS11可能与自身免疫反应的异常调控相关。
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**提示**：实际研究中，建议通过PubMed、Web of Science等平台，以“RPS11 antibody”“RPS11 biomarker”等关键词检索最新文献。
The RPS11 antibody is a tool used to detect ribosomal protein S11 (RPS11), a component of the 40S ribosomal subunit involved in mRNA translation. RPS11. encoded by the *RPS11* gene (located on human chromosome 19q13.2), plays a critical role in ribosome biogenesis and protein synthesis. Beyond its canonical function, RPS11 has been implicated in non-ribosomal roles, including DNA repair, cell cycle regulation, and stress responses. Dysregulation of RPS11 is linked to various diseases, such as cancer (e.g., hepatocellular carcinoma, colorectal cancer) and Diamond-Blackfan anemia, a ribosomopathy characterized by bone marrow failure.
RPS11 antibodies (polyclonal or monoclonal) are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, localization, and interactions. They are often validated using knockdown models or recombinant protein controls to ensure specificity. Research utilizing these antibodies has shed light on RPS11’s role in tumor progression, where its overexpression may promote oncogenesis, and in cellular stress pathways, such as p53-mediated apoptosis. Additionally, studies explore its interaction with viral RNA during infections, highlighting its broader functional relevance.
As ribosome-related research expands, RPS11 antibodies remain vital for understanding translational regulation, disease mechanisms, and potential therapeutic targets. Their application bridges basic ribosome biology and clinical investigations, underscoring the importance of RPS11 in health and disease.
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