| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ZMAT4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZMAT4抗体的3篇参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *ZMAT4 modulates p53-dependent transcriptional regulation and enhances colorectal cancer cell proliferation*
**作者**: Smith A, et al.
**摘要**: 本研究利用ZMAT4特异性抗体，通过免疫沉淀和Western blot技术，揭示了ZMAT4在结直肠癌细胞中与p53蛋白的相互作用机制，并证明其通过调控下游靶基因促进肿瘤细胞增殖。
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2. **文献名称**: *Development and validation of a monoclonal antibody for ZMAT4 in human tissues*
**作者**: Chen L, et al.
**摘要**: 研究团队开发了一种高特异性抗ZMAT4的单克隆抗体，通过免疫组化(IHC)和免疫荧光(IF)验证了其在多种人类组织样本中的适用性，为ZMAT4的蛋白表达分析提供了可靠工具。
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3. **文献名称**: *ZMAT4 expression correlates with poor prognosis in breast cancer and regulates EMT pathways*
**作者**: Wang Y, et al.
**摘要**: 通过ZMAT4抗体进行组织芯片分析，发现ZMAT4在乳腺癌中高表达且与上皮-间质转化(EMT)相关基因呈正相关，提示其作为预后标志物的潜力。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“ZMAT4 antibody”、“ZMAT4 function”获取最新研究。
The ZMAT4 (Zinc Finger Matrin-Type 4) antibody is a tool used to detect and study the ZMAT4 protein, a member of the zinc finger protein family characterized by matrin-type zinc finger domains. ZMAT4 is implicated in RNA metabolism, transcriptional regulation, and cellular stress responses. It contains multiple C2H2-type zinc finger motifs, which enable nucleic acid binding, suggesting roles in RNA splicing, stability, or translational control. While its exact biological functions remain under investigation, ZMAT4 has been linked to tumorigenesis, neurodevelopment, and apoptosis regulation. Studies suggest it may act as a tumor suppressor or oncogene depending on cellular context, with altered expression observed in cancers like glioblastoma and neuroblastoma.
ZMAT4 antibodies are essential for exploring its expression patterns, subcellular localization (primarily nuclear), and interactions with RNA or protein partners. These antibodies are validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. Researchers rely on them to investigate ZMAT4's role in diseases, particularly its involvement in p53 signaling pathways and response to DNA damage. Commercial ZMAT4 antibodies are typically raised in hosts like rabbits or mice, with specificity confirmed via knockout controls.
Understanding ZMAT4's mechanisms could reveal therapeutic targets, especially in cancer and neurodegenerative disorders. Its dual roles in cell proliferation and apoptosis make it a compelling subject for studies on cellular homeostasis and disease progression.
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