关键信息
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基因名
TCN1
- 应用
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别名
Haptocorrin Short name: HC Protein R Transcobalamin I Short name: TC I Short name: TCI
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20061
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表达区间
24-433aa
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分子量
61.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TCN1 (T-complex protein 1 subunit gamma) is a member of the chaperonin-containing TCP1 (CCT) complex, which plays a crucial role in the proper folding of newly synthesized proteins, particularly those involved in cellular stress responses and cytoskeletal assembly. The importance of TCN1 in cellular function is underscored by its involvement in essential biological processes, such as signal transduction, cell motility, and development. Mutations or dysregulation of TCN1 have been implicated in various diseases, including cancer and neurodegenerative disorders, making it a target of interest for therapeutic interventions. Thus, the study of recombinant TCN1 protein is essential for understanding its structure-function relationships and the molecular mechanisms of its action. Recombinant protein studies facilitate the investigation of TCN1's chaperone activities, its interactions with other proteins, and its role in the assembly of multi-subunit complexes. By producing TCN1 in a recombinant system, researchers can obtain large quantities of pure protein for in vitro assays, structural biology studies, and potential drug screening applications. Furthermore, uncovering the functional properties of TCN1 may reveal novel insights into the development of targeted therapies and provide valuable information for the design of interventions aimed at correcting the misfolding of proteins linked to various diseases. Through a better understanding of TCN1's biochemical properties and biological significance, researchers aim to elucidate its contribution to cellular homeostasis and the pathogenesis of diseases associated with protein misfolding and aggregation.
