WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/25-1/100 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
Aliases | TTF2; FOXE2; HFKH4; HFKL5; TITF2; TTF-2; FKHL15 |
WB Predicted band size | 38 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human FOXE1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOXE1抗体的3篇参考文献示例(注:文献为虚构示例,实际引用需查询真实数据库):
1. **文献名称**:FOXE1 expression in thyroid development and cancer
**作者**:Smith A, et al.
**摘要**:本研究利用FOXE1抗体通过免疫组化分析胚胎甲状腺组织,揭示了FOXE1在甲状腺滤泡细胞分化中的关键作用,并发现其在甲状腺癌中表达异常下调。
2. **文献名称**:Role of FOXE1 in oropharyngeal squamous cell carcinoma
**作者**:Chen L, et al.
**摘要**:通过Western blot和免疫荧光技术,作者使用FOXE1抗体证实了FOXE1蛋白在头颈部鳞状细胞癌中的高表达,提示其可能作为癌症侵袭性的生物标志物。
3. **文献名称**:FOXE1 mutations and protein localization in congenital hypothyroidism
**作者**:Garcia R, et al.
**摘要**:该研究通过FOXE1抗体进行免疫染色,发现FOXE1基因突变患者甲状腺组织中蛋白定位异常,阐明了部分先天性甲状腺功能减退症的分子机制。
(提示:实际研究中建议通过PubMed或Google Scholar搜索“FOXE1 antibody application”或“FOXE1 immunohistochemistry”获取真实文献。)
FOXE1 (Forkhead Box E1), also known as Thyroid Transcription Factor 2 (TTF-2), is a transcription factor encoded by the FOXE1 gene on chromosome 9q22. It belongs to the forkhead/winged-helix family of DNA-binding proteins and plays critical roles in embryonic development, particularly in thyroid morphogenesis, palate formation, and hair follicle differentiation. FOXE1 regulates the expression of thyroid-specific genes, including thyroglobulin and thyroid peroxidase, and is essential for the migration of thyroid precursor cells during organogenesis.
Mutations in FOXE1 are associated with congenital thyroid disorders, such as thyroid agenesis or dysgenesis, and Bamforth-Lazarus syndrome, characterized by cleft palate, spiky hair, and thyroid dysfunction. Dysregulated FOXE1 expression has also been implicated in thyroid cancer, where it may act as a tumor suppressor or context-dependent oncogene.
FOXE1 antibodies are immunological tools used to detect and quantify FOXE1 protein levels in research and diagnostics. These antibodies are pivotal in studying thyroid development, genetic disorders, and cancer mechanisms via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available FOXE1 antibodies are typically validated for specificity and sensitivity, aiding in identifying FOXE1 localization in tissues or cellular models. Their applications extend to exploring FOXE1's role in epithelial-mesenchymal transitions and potential therapeutic targets in oncology.
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