WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
Aliases | GASR, CCK-B, CCK2R |
WB Predicted band size | 49 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide of human CCKBR |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CCKBR抗体的3篇代表性文献的示例(内容为虚构模拟,仅作格式参考):
1. **文献名称**:*Targeting CCKBR in gastric cancer with a novel monoclonal antibody*
**作者**:Smith A, et al.
**摘要**:研究开发了一种针对CCKBR的高特异性单克隆抗体,证实其能抑制胃癌细胞增殖并增强化疗敏感性,为靶向治疗提供新策略。
2. **文献名称**:*CCKBR antibody-based immunohistochemical detection in neuroendocrine tumors*
**作者**:Yamamoto K, et al.
**摘要**:利用CCKBR抗体建立免疫组化检测方法,发现其在神经内分泌肿瘤中高表达,提示其作为诊断标志物的潜在价值。
3. **文献名称**:*Mechanistic role of CCKBR antibody in regulating receptor signaling*
**作者**:Lee J, et al.
**摘要**:通过阻断CCKBR的抗体实验,揭示了该受体在MAPK/ERK信号通路中的调控机制,及其在炎症反应中的作用。
(注:以上文献为示例,实际引用需查询PubMed或学术数据库获取真实文献。)
The cholecystokinin B receptor (CCKBR), also known as CCK-B receptor or CCK2R, is a G protein-coupled receptor (GPCR) primarily activated by gastrin and cholecystokinin (CCK). It plays a critical role in regulating gastric acid secretion, cell proliferation, and digestive processes. Structurally, CCKBR contains seven transmembrane domains and interacts with Gq proteins, triggering intracellular signaling pathways like phospholipase C (PLC) activation and calcium mobilization.
CCKBR is expressed in the stomach, brain, and certain cancers. Overexpression of CCKBR has been linked to gastrointestinal disorders (e.g., Zollinger-Ellison syndrome) and malignancies, including gastric, colorectal, and pancreatic cancers, where it promotes tumor growth and metastasis. In the central nervous system, it modulates anxiety, memory, and pain perception.
CCKBR antibodies are essential tools for studying receptor localization, expression levels, and function in physiological and pathological contexts. They are used in techniques like immunohistochemistry, Western blotting, and flow cytometry to investigate CCKBR's role in disease mechanisms or therapeutic targeting. Additionally, CCKBR-specific antibodies are explored for diagnostic applications and as potential therapeutic agents to block aberrant signaling in cancers. Research continues to optimize antibody specificity and develop conjugates for imaging or drug delivery.
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