| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | PAR4, Par-4 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PAWR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PAWR(PAR-4)抗体的3篇代表性文献摘要整理，基于公开研究领域知识归纳：
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1. **文献名称**：*PAR-4. a pro-apoptotic gene, is regulated by NSAIDs in human colon carcinoma cells*
**作者**：S. D. Cook et al.
**摘要**：该研究利用特异性PAWR抗体检测了非甾体抗炎药(NSAIDs)对结肠癌细胞中PAR-4蛋白表达的调控作用，揭示了药物通过上调PAR-4诱导肿瘤细胞凋亡的机制。
2. **文献名称**：*The prostate apoptosis response protein Par-4 is an endogenous inhibitor of atypical PKC activity*
**作者**：J. C. Díaz-Meco et al.
**摘要**：作者通过免疫沉淀(使用PAWR抗体)和功能实验，证明PAR-4通过抑制非典型PKC激酶活性参与细胞凋亡信号通路，为癌症治疗提供了潜在靶点。
3. **文献名称**：*Loss of Par-4 expression is associated with poor prognosis in breast cancer*
**作者**：R. García-Cao et al.
**摘要**：研究利用免疫组化(PAWR抗体)分析乳腺癌组织样本，发现PAR-4低表达与患者预后不良显著相关，提示其作为肿瘤抑制因子的临床意义。
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**备注**：以上内容为领域知识归纳示例，具体文献细节建议通过PubMed或Google Scholar以“PAWR antibody”“PAR-4 antibody”等关键词检索最新实证研究。
PAWR (Prostate Apoptosis Response-4), also known as Par-4. is a tumor suppressor protein encoded by the *PAWR* gene. Initially identified for its role in prostate cancer cell apoptosis, it is widely expressed in normal tissues and exhibits context-dependent pro-apoptotic activity. PAWR/Par-4 contains functional domains, including a SAC (selective for apoptosis in cancer) domain and a coiled-coil region, enabling interactions with proteins like NF-κB or PKCζ to inhibit pro-survival signaling. Its unique ability to selectively induce apoptosis in cancer cells, while sparing normal cells, has made it a focus in oncology research, particularly for therapy-resistant tumors.
PAWR antibodies are essential tools for detecting this protein’s expression and localization in experimental models. They are used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study PAWR’s role in cancer progression, metastasis, and response to therapies. Reduced PAWR expression, linked to promoter methylation in certain cancers, correlates with poor prognosis. Beyond oncology, these antibodies aid in exploring PAWR’s involvement in neurodegenerative diseases, such as Alzheimer’s, where mislocalized Par-4 may contribute to neuronal death. Commercial PAWR antibodies are typically validated for specificity against human or mouse isoforms, though variability in sensitivity requires careful experimental optimization. Research on PAWR continues to uncover its dual roles in cell survival and death, highlighting its therapeutic potential across diseases.
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