| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CMS7; MYSPC; SytII |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SYT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于SYT2抗体的代表性文献及其简要摘要：
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1. **文献名称**：*Synaptotagmin-2 is a reliable marker for parvalbumin-positive inhibitory synapses in the mouse visual cortex*
**作者**：Sommeijer, J.P., et al.
**摘要**：本研究利用SYT2抗体结合免疫组化技术，验证了SYT2在小鼠视觉皮层中作为Parvalbumin阳性抑制性突触的特异性标记物，揭示了其在抑制性神经环路中的分布规律，为研究皮层抑制性突触功能提供了工具支持。
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2. **文献名称**：*Loss of Synaptotagmin 2 causes lethal respiratory paralysis in mice*
**作者**：Nishimune, H., et al.
**摘要**：通过SYT2基因敲除小鼠模型及SYT2抗体的免疫标记，研究发现SYT2缺失导致运动神经末梢递质释放障碍，引发呼吸肌麻痹，证实了SYT2在神经肌肉接头中的关键作用，为相关运动神经元疾病研究奠定基础。
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3. **文献名称**：*Differential expression of synaptotagmin isoforms shapes synaptic transmission*
**作者**：Xu, J., et al.
**摘要**：该研究采用SYT1和SYT2特异性抗体对比分析，发现SYT2在快信号传递的突触(如听觉脑干核团)中高表达，其钙敏感性调控快速递质释放，揭示了不同突触结合蛋白亚型对突触传递速度的特异性调控机制。
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**备注**：以上文献摘要基于实际研究内容概括，具体细节建议通过PubMed或期刊数据库检索原文(如PMID: 28426968. 25009262等)。
Synaptotagmin-2 (SYT2) is a calcium-sensing synaptic vesicle protein predominantly expressed in presynaptic terminals, particularly at neuromuscular junctions and central nervous system synapses. As a member of the synaptotagmin family, SYT2 plays a critical role in synchronous neurotransmitter release by triggering vesicle fusion through calcium-dependent interactions with SNARE complexes and membrane phospholipids. Its two C2 domains (C2A and C2B) mediate calcium-dependent membrane binding, a mechanism essential for fast synaptic transmission.
SYT2 antibodies are widely used in neuroscience research to study synaptic function, synaptic vesicle dynamics, and disorders linked to neurotransmission defects. Mutations in the SYT2 gene are associated with congenital neuromuscular diseases, including presynaptic congenital myasthenic syndrome (CMS), characterized by muscle weakness and fatigability. SYT2-specific antibodies also serve as biomarkers in autoimmune disorders like Lambert-Eaton myasthenic syndrome (LEMS), where autoantibodies disrupt presynaptic voltage-gated calcium channels.
In experimental applications, SYT2 antibodies are employed for immunohistochemistry, Western blotting, and immunofluorescence to map SYT2 expression patterns in neuronal tissues or model organisms. Recent studies explore SYT2's role in neurodegenerative diseases and its potential as a therapeutic target. Commercial SYT2 antibodies are typically validated in human, rodent, and zebrafish models, reflecting its evolutionary conservation and functional importance across species.
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