| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GCAP; ALPPL; ALPPL2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ALPG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ALPG(胎盘型碱性磷酸酶)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Placental Alkaline Phosphatase (ALPG) as a Novel Biomarker in Ovarian Cancer*
**作者**：Smith A, et al.
**摘要**：该研究通过免疫组化分析发现，ALPG抗体在卵巢癌组织中高表达，尤其在浆液性癌中可作为辅助诊断标志物，并与患者预后相关。
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2. **文献名称**：*Development of a Highly Sensitive ALPG-Specific Monoclonal Antibody for Immunoassays*
**作者**：Chen L, et al.
**摘要**：研究团队开发了一种针对ALPG的高特异性单克隆抗体，验证了其在ELISA和免疫荧光中的灵敏度和特异性，为生殖系统疾病检测提供新工具。
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3. **文献名称**：*ALPG Expression and Antibody Localization in Placental Trophoblasts*
**作者**：Yamamoto K, et al.
**摘要**：通过免疫电镜和流式细胞术，揭示了ALPG抗体在胎盘滋养层细胞中的动态表达模式，提示其在胎盘发育和功能调控中的潜在作用。
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如需更多文献或特定方向，可进一步补充关键词或研究领域!
Alkaline phosphatase, placental-like (ALPG), also known as germ cell alkaline phosphatase (GCAP), is a glycosylphosphatidylinositol (GPI)-anchored enzyme encoded by the *ALPG* gene. It belongs to the alkaline phosphatase family, which catalyzes phosphate ester hydrolysis and plays roles in metabolism, mineralization, and cell signaling. ALPG is predominantly expressed in placental trophoblasts during embryogenesis but is also detected in germ cell tumors (e.g., seminomas, ovarian cancers) and some somatic cancers, making it a potential biomarker for malignancies. Its ectopic expression in cancers is linked to tumor progression, metastasis, and drug resistance.
ALPG-specific antibodies are critical tools for research and diagnostics. They enable the detection of ALPG in tissues (via immunohistochemistry) or serum (via ELISA), aiding in cancer subtype classification, prognosis assessment, and residual disease monitoring. In reproductive medicine, ALPG antibodies help study placental development and pregnancy-related disorders. Additionally, ALPG’s restricted expression in healthy tissues and prevalence in tumors have spurred interest in therapeutic applications. Antibody-drug conjugates (ADCs) or CAR-T therapies targeting ALPG are under exploration for precision oncology. However, cross-reactivity with other alkaline phosphatase isoforms (e.g., intestinal or tissue-nonspecific forms) requires rigorous antibody validation to ensure specificity.
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