| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BDM1; SMAP8; SMAP-8 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human NDRG4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于NDRG4抗体的3篇参考文献示例(文献信息为模拟内容，实际引用需核对原文)：
1. **"NDRG4: A novel tumor suppressor and biomarker in colorectal cancer"**
- 作者：Melotte V, et al.
- 摘要：研究通过免疫组化(使用NDRG4特异性抗体)发现NDRG4在结直肠癌组织中表达显著下调，且其低表达与患者预后不良相关，提示NDRG4可作为潜在诊断标志物和抑癌基因。
2. **"Epigenetic silencing of NDRG4 promotes glioblastoma progression"**
- 作者：Li Y, et al.
- 摘要：通过Western blot和免疫荧光(NDRG4抗体验证)证明NDRG4在胶质母细胞瘤中因启动子甲基化而表达缺失，恢复其表达可抑制肿瘤细胞侵袭，表明其在肿瘤抑制中的作用。
3. **"Antibody-based detection of NDRG4 in stool: A non-invasive screening tool for colorectal cancer"**
- 作者：de Vos T, et al.
- 摘要：开发了一种基于NDRG4抗体的粪便检测方法，用于结直肠癌早期筛查。研究显示NDRG4甲基化与蛋白表达缺失高度相关，该检测方法灵敏度达85%。
4. **"NDRG4 expression in Alzheimer's disease brain: Implications for neuronal survival"**
- 作者：Zhou X, et al.
- 摘要：利用NDRG4抗体进行免疫组化和Western blot分析，发现NDRG4在阿尔茨海默病患者脑组织中表达降低，可能通过调节神经元凋亡通路参与疾病进程。
(注：以上文献为示例，实际引用请通过PubMed或学术数据库核对原文信息。)
The NDRG4 (N-Myc downstream-regulated gene 4) antibody is a tool used to detect and study the NDRG4 protein, a member of the NDRG family involved in cellular processes like differentiation, stress response, and tumor suppression. NDRG4. also termed BDM1 or SMAP-8. is highly expressed in the brain, heart, and gastrointestinal tissues, with roles in neuronal development, myelination, and cardiovascular function. Its dysregulation has been linked to cancers (e.g., colorectal, pancreatic), neurodegenerative disorders (e.g., Alzheimer’s), and heart diseases. Structurally, it contains an α/β hydrolase-fold domain, though its enzymatic function remains unclear.
NDRG4 antibodies are critical for research applications such as Western blotting, immunohistochemistry, and immunofluorescence, enabling the visualization of protein expression patterns and localization. These antibodies aid in exploring NDRG4's dual role as a tumor suppressor (via cell cycle arrest and apoptosis induction) or promoter (context-dependent). They also help investigate its interaction with signaling pathways like Wnt/β-catenin and PTEN/AKT. Validated for specificity and sensitivity, NDRG4 antibodies are essential for advancing studies on disease mechanisms, biomarker discovery, and therapeutic targeting.
×
