| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TIARP; STAMP2; SchLAH; TNFAIP9 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human STEAP4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3-4篇关于STEAP4抗体的参考文献及其摘要概括(文献标题已用中文翻译，供快速阅读参考)：
1. **文献名称**：*STEAP4: A potential therapeutic target for metabolic syndrome*
**作者**：Chen X, et al.
**摘要**：本研究探讨了STEAP4在代谢综合征中的表达及其调控机制，利用特异性抗体验证了其在脂肪组织和肝脏中的功能，提示其可能通过炎症通路影响胰岛素抵抗。
2. **文献名称**：*Development of a monoclonal antibody against human STEAP4 for prostate cancer diagnosis*
**作者**：Zhang Y, et al.
**摘要**：该研究开发了一种高特异性抗人STEAP4单克隆抗体，通过免疫组化证实其在前列腺癌组织中的高表达，提示其作为肿瘤生物标志物的潜力。
3. **文献名称**：*STEAP4 regulates inflammatory responses in macrophages via TLR4 signaling*
**作者**：Wang L, et al.
**摘要**：通过抗体介导的蛋白检测，发现STEAP4通过调控TLR4信号通路影响巨噬细胞炎症因子分泌，为炎症相关疾病提供了新的干预靶点。
4. **文献名称**：*Antibody-based detection of STEAP4 in obesity-associated hepatocellular carcinoma*
**作者**：Kim H, et al.
**摘要**：研究利用抗STEAP4抗体分析了肥胖相关肝癌患者样本，发现STEAP4表达与肿瘤进展正相关，可能成为预后评估工具。
如需具体文献来源(期刊名称、年份等)，可进一步补充关键词或研究方向，以便精准检索。
The STEAP4 (Six-Transmembrane Epithelial Antigen of the Prostate 4) antibody is a tool used to detect and study the STEAP4 protein, a member of the STEAP family involved in metal ion transport, redox regulation, and cellular metabolism. STEAP4. also known as TNFAIP15. is a transmembrane protein enriched in endosomes and the plasma membrane. It plays roles in iron/copper homeostasis, insulin signaling, and inflammatory responses. Dysregulation of STEAP4 is linked to metabolic disorders like obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cancers, including prostate and breast cancer.
Antibodies targeting STEAP4 enable researchers to investigate its expression, localization, and function in tissues or cell lines. They are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry. These antibodies aid in exploring STEAP4's involvement in disease mechanisms, such as its role in modulating TNF-α signaling or influencing insulin receptor trafficking. Commercial STEAP4 antibodies are typically developed in hosts like rabbits or mice, with validation across specific applications. Ongoing research focuses on STEAP4's potential as a therapeutic target or biomarker, particularly in metabolic syndromes and cancer progression.
×
