| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AP-2B; AP2-B |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TFAP2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及TFAP2B抗体的参考文献示例(文献信息为模拟虚构，仅供格式参考)：
1. **文献名称**：*TFAP2B mutations and transcriptional regulation in Char syndrome*
**作者**：Satoda M, et al.
**摘要**：本研究利用TFAP2B特异性抗体进行免疫沉淀和染色质分析，揭示了TFAP2B基因突变如何通过破坏转录调控导致Char综合征(先天性心脏病合并颅面异常)。
2. **文献名称**：*Role of TFAP2B in adipocyte differentiation and obesity-related pathways*
**作者**：Hilger-Eversheim K, et al.
**摘要**：通过Western blot和免疫荧光技术，该研究证实TFAP2B抗体可特异性检测脂肪细胞分化过程中TFAP2B蛋白的表达上调，并阐明其调控脂肪生成的关键作用。
3. **文献名称**：*TFAP2B expression in renal development and disease models*
**作者**：Zhang Y, et al.
**摘要**：采用TFAP2B抗体进行小鼠肾脏组织免疫组化分析，发现TFAP2B在肾小管发育中的时空特异性表达，并探讨其与先天性肾脏畸形的关系。
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**备注**：以上文献为示例，实际引用时请通过PubMed或Google Scholar检索关键词“TFAP2B antibody”+“研究领域(如疾病或技术)”获取真实文献。
The TFAP2B antibody is a tool used to detect the transcription factor AP-2 beta (TFAP2B), a member of the AP-2 family of DNA-binding proteins. TFAP2B plays critical roles in embryonic development, particularly in the formation of kidneys, limbs, craniofacial structures, and neural crest-derived tissues. It regulates gene expression by binding to specific DNA sequences, influencing cell differentiation, proliferation, and survival. Structurally, TFAP2B contains a helix-span-helix dimerization domain and a basic region for DNA interaction, along with transactivation domains.
Antibodies targeting TFAP2B are widely used in research to study its expression patterns, molecular interactions, and functional roles in both normal development and disease. They are applied in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). TFAP2B dysregulation has been linked to genetic disorders such as Char syndrome (characterized by patent ductus arteriosus and craniofacial anomalies) and metabolic conditions like obesity, where TFAP2B variants may influence adipose tissue biology. Studies also explore its potential role in cancer, particularly neuroblastoma and breast cancer. Researchers rely on TFAP2B antibodies to validate protein expression in model systems, assess tissue-specific localization, and investigate mechanisms underlying these pathologies. Both monoclonal and polyclonal versions are available, with validation specificity being crucial due to homology among AP-2 family members.
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