| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TSBP; p150; SH2BP1; p150TSP |
| WB Predicted band size | 134 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CTR9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CTR9抗体的3篇参考文献的简要信息：
1. **文献名称**：*CTR9 drives osteosarcoma progression through upregulating the Wnt/β-catenin pathway*
**作者**：Zhang Y, et al.
**摘要**：研究利用CTR9抗体进行免疫沉淀和Western blot分析，发现CTR9通过激活Wnt/β-catenin通路促进骨肉瘤细胞增殖和转移，提示其作为潜在治疗靶点。
2. **文献名称**：*The PAF1 complex component CTR9 regulates embryonic stem cell differentiation*
**作者**：Chen X, et al.
**摘要**：通过CTR9抗体的ChIP-seq实验，揭示CTR9作为PAF1复合物成员，调控多能性基因(如OCT4)的表观遗传修饰，影响胚胎干细胞分化进程。
3. **文献名称**：*CTR9 deficiency inhibits tumorigenesis in colorectal cancer via suppressing histone H3K4 trimethylation*
**作者**：Li H, et al.
**摘要**：研究使用CTR9抗体进行免疫组化分析，证明CTR9缺失通过降低H3K4me3水平抑制结直肠癌生长，其表达与患者预后负相关。
注：以上文献信息为基于领域研究的模拟概括，实际引用需查询具体论文数据库(如PubMed)。
The CTR9 antibody targets the CTR9 protein, a key subunit of the Polymerase-Associated Factor 1 (PAF1) complex, which is evolutionarily conserved and plays multifaceted roles in transcriptional regulation, histone modification, and mRNA processing. The PAF1 complex, comprising CTR9. LEO1. PAF1. CDC73. and RTF1. associates with RNA polymerase II, influencing elongation and epigenetic marks like H2B ubiquitination and H3K4 methylation. CTR9 is critical for maintaining complex stability and recruiting additional partners.
Research highlights CTR9's involvement in embryonic development, stem cell pluripotency, and oncogenesis. It regulates Wnt/β-catenin signaling and MYC expression, linking it to cancers such as colorectal carcinoma and breast cancer. Dysregulation of CTR9 correlates with tumor progression, metastasis, and poor prognosis, suggesting its dual role as an oncogene or tumor suppressor depending on context.
CTR9 antibodies are essential tools for studying these mechanisms, enabling detection of protein _expression (via Western blot, immunofluorescence, or immunohistochemistry), mapping interactions (co-immunoprecipitation), and exploring clinical associations. Recent studies also probe CTR9's potential as a therapeutic target or biomarker. However, functional heterogeneity across tissues and diseases necessitates careful experimental validation to ensure antibody specificity and relevance to particular biological or pathological models.
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