| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PAC1; PAC-1 |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DUSP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DUSP2抗体的参考文献示例(注：以下内容为模拟虚构，仅供参考)：
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1. **文献名称**: *"DUSP2 modulates macrophage polarization via MAPK signaling in inflammatory responses"*
**作者**: Smith A, et al.
**摘要**: 本研究利用DUSP2特异性抗体，通过Western blot和免疫荧光技术，揭示DUSP2通过调控p38和ERK磷酸化影响巨噬细胞极化，敲除DUSP2后促炎因子(如TNF-α、IL-6)表达显著升高，表明其在炎症反应中的关键作用。
2. **文献名称**: *"DUSP2 as a prognostic biomarker in colorectal cancer: Immunohistochemical analysis"*
**作者**: Zhang L, et al.
**摘要**: 通过抗DUSP2抗体的免疫组化染色，发现结直肠癌组织中DUSP2表达水平与患者生存率相关。低表达患者预后较差，提示DUSP2可能通过抑制MAPK通路发挥抑癌作用。
3. **文献名称**: *"Generation and validation of a high-affinity monoclonal antibody for human DUSP2 detection"*
**作者**: Brown K, et al.
**摘要**: 研究报道了一种新型抗人DUSP2单克隆抗体的开发，经ELISA、流式细胞术和免疫沉淀验证，证实其高特异性和敏感性，适用于多种实验场景，为DUSP2功能研究提供可靠工具。
4. **文献名称**: *"DUSP2 regulates T cell activation through dynamic ERK dephosphorylation"*
**作者**: Lee J, et al.
**摘要**: 利用DUSP2抗体进行蛋白质定位及磷酸化分析，发现DUSP2通过负调控ERK磷酸化影响T细胞活化和增殖，为自身免疫疾病治疗提供潜在靶点。
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以上文献摘要聚焦DUSP2抗体的实验应用(如蛋白检测、疾病机制研究及抗体开发)，覆盖炎症、癌症和免疫调节领域，符合常见研究场景。
The DUSP2 antibody is a research tool designed to detect and study dual-specificity phosphatase 2 (DUSP2), a member of the MAP kinase phosphatase (MKP) family. DUSP2. also known as PAC-1. regulates mitogen-activated protein kinase (MAPK) signaling by dephosphorylating and inactivating ERK, JNK, and p38 kinases. It plays a critical role in immune responses, cell proliferation, and apoptosis. DUSP2 is notably expressed in immune cells, including macrophages, where it modulates inflammatory signaling pathways.
Antibodies targeting DUSP2 are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to analyze protein expression, localization, and function. Researchers employ these antibodies to investigate DUSP2's involvement in diseases such as cancer, autoimmune disorders, and chronic inflammation. For instance, studies suggest DUSP2 downregulation in certain tumors may enhance MAPK-driven oncogenic signaling, while its overexpression in inflammatory conditions could suppress pro-inflammatory cytokine production.
Validating DUSP2 antibody specificity is crucial, often achieved through knockout controls or peptide blocking experiments. Its applications extend to understanding cellular responses to stress, growth factors, and therapeutic agents targeting MAPK pathways. As dysregulated DUSP2 expression correlates with pathological states, this antibody remains vital for elucidating molecular mechanisms in immunology, oncology, and drug development research.
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