| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FLJ92027; H2A histone family, member C; H2A.1; H2A/c; H2A1; H2AFC; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM;;p-Histone H2A (S129) |
| WB Predicted band size | 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Yeast |
| Immunogen | A synthesized peptide derived from yeast Histone H2A around the phosphorylation site of S129 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ADGRA2抗体的虚构参考文献示例(实际文献需通过学术数据库检索)：
1. **"ADGRA2 regulates neural progenitor migration during cortical development"**
- 作者：Smith J, et al.
- 摘要：本研究利用ADGRA2特异性抗体揭示了该蛋白在胚胎小鼠脑发育中调控神经前体细胞迁移的机制，抗体通过免疫荧光验证了其在皮层中的表达模式。
2. **"ADGRA2 as a novel biomarker in colorectal cancer progression"**
- 作者：Lee H, et al.
- 摘要：通过ADGRA2抗体的免疫组化分析，发现其在结直肠癌组织中高表达，并与患者预后不良相关，提示其可能作为潜在治疗靶点。
3. **"Characterization of a monoclonal antibody targeting ADGRA2 extracellular domain"**
- 作者：Wang Y, et al.
- 摘要：开发了一种针对ADGRA2胞外域的单克隆抗体，验证了其特异性及在流式细胞术和Western blot中的应用，为后续功能研究提供工具。
4. **"ADGRA2 modulates Wnt signaling in endothelial cell angiogenesis"**
- 作者：Garcia R, et al.
- 摘要：使用ADGRA2抗体阻断实验证明其通过调控Wnt/β-catenin通路影响血管内皮细胞迁移，提示其在血管生成中的潜在作用。
The ADGRA2 (Adhesion G Protein-Coupled Receptor A2) antibody is a tool used to study the expression and function of ADGRA2. a member of the adhesion G protein-coupled receptor (GPCR) family. ADGRA2. also known as GPR124. is a transmembrane receptor characterized by a large extracellular N-terminus containing adhesion-related domains, such as leucine-rich repeats and immunoglobulin-like motifs. It plays critical roles in vascular and neural development, particularly in blood-brain barrier formation, angiogenesis, and central nervous system (CNS) patterning. ADGRA2 interacts with Wnt signaling pathways, acting as a co-receptor for Wnt7 ligands to regulate β-catenin-dependent signaling, essential for endothelial cell function and tissue homeostasis.
The ADGRA2 antibody is widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in elucidating ADGRA2's involvement in diseases, including cancer, where its dysregulation is linked to tumor angiogenesis and metastasis, and cerebrovascular disorders. Studies also explore its role in neuroinflammatory conditions and developmental anomalies. Validated for specificity and sensitivity, the antibody enables spatial and temporal analysis of ADGRA2 in biological samples, contributing to mechanistic insights and potential therapeutic targeting. Ongoing research continues to uncover its physiological and pathological significance across diverse tissues.
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