| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human REG3A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于REG3A抗体的参考文献(信息基于公开研究整理)：
1. **文献名称**: *"REG3A promotes pancreatic cancer pathogenesis through immunomodulation and proliferation"*
**作者**: Li Y. et al.
**摘要**: 研究利用REG3A特异性抗体证实其在胰腺癌组织中高表达，并揭示其通过激活STAT3通路促进肿瘤细胞增殖，同时调控肿瘤微环境中免疫细胞的浸润。
2. **文献名称**: *"REG3A maintains intestinal barrier function via modulating mucin production"*
**作者**: Zhang H. et al.
**摘要**: 通过免疫组化(REG3A抗体标记)和基因敲除模型，发现REG3A通过调控黏蛋白合成增强肠道屏障功能，其缺失可能导致肠道炎症和菌群失调。
3. **文献名称**: *"Overexpression of REG3A correlates with poor prognosis in hepatocellular carcinoma"*
**作者**: Wang X. et al.
**摘要**: 使用REG3A抗体对肝癌组织进行染色，发现其高表达与患者生存期缩短相关，机制涉及促进肿瘤细胞迁移和抑制凋亡。
4. **文献名称**: *"REG3A as a biomarker for inflammatory bowel disease progression"*
**作者**: Chen L. et al.
**摘要**: 通过ELISA和Western blot(基于REG3A抗体)检测患者血清及组织样本，表明REG3A水平与IBD严重程度呈正相关，可能成为疾病监测的潜在标志物。
(注：以上文献为示例性内容，实际引用时需核实具体论文信息。)
The REG3A antibody is a research tool designed to detect REG3A (Regenerating Islet-Derived Protein 3 Alpha), a secreted protein belonging to the REG family of C-type lectins. REG3A, also known as pancreatic secretory protein (PAP) or hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP), is primarily expressed in the gastrointestinal tract, pancreas, and other tissues. It plays a role in cell proliferation, tissue repair, and antimicrobial activity, particularly in maintaining gut barrier function by targeting peptidoglycan components of bacterial cell walls.
REG3A is upregulated during inflammation, infection, or tissue injury, making it a biomarker for conditions like inflammatory bowel disease (IBD), pancreatitis, and certain cancers. Its overexpression has been observed in gastrointestinal cancers, where it may promote tumor progression via pathways involving cell survival and metastasis.
The REG3A antibody is widely used in techniques such as immunohistochemistry, Western blotting, and ELISA to study its expression patterns, localization, and regulatory mechanisms in both normal and diseased states. Researchers utilize this antibody to explore REG3A's dual roles in host defense and disease pathogenesis, aiming to clarify its potential as a therapeutic target or diagnostic marker. Understanding REG3A's functions could advance treatments for infections, chronic inflammation, and cancer.
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