| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | P2X2; DFNA41 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human P2RX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于P2RX2抗体的代表性文献摘要，供参考：
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1. **文献名称**：*Selective knockdown of P2X2 receptors in mouse cochlear hair cells attenuates noise-induced hearing loss*
**作者**：Yan et al.
**摘要**：利用P2RX2特异性抗体进行免疫荧光定位，证实P2X2受体在耳蜗毛细胞中高表达。通过抗体阻断实验发现，抑制P2X2可减少噪声暴露后的钙内流，从而减轻听觉损伤，提示其作为治疗靶点的潜力。
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2. **文献名称**：*P2X2 receptor antagonism reduces neuronal hyperactivity and improves survival in a rat model of sepsis-associated encephalopathy*
**作者**：Li et al.
**摘要**：研究使用抗P2RX2抗体阻断中枢神经系统中的P2X2受体，发现可显著降低脓毒症模型大鼠的神经元过度兴奋和炎症因子释放，为脓毒症脑病提供了新的干预策略。
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3. **文献名称**：*Antibody-based detection of P2X2 receptor in pancreatic β-cells reveals ATP-mediated insulin secretion regulation*
**作者**：Zhang et al.
**摘要**：通过Western blot和免疫组化技术，利用P2RX2抗体证实该受体在胰岛β细胞中的表达，并发现ATP通过激活P2X2受体促进胰岛素分泌，为糖尿病机制研究提供新视角。
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**备注**：若需获取具体文献全文或扩展研究领域(如免疫调节、肿瘤微环境等)，可进一步补充关键词或应用场景。
The P2RX2 antibody is a research tool designed to target the P2X purinoreceptor 2 (P2RX2), a ligand-gated ion channel activated by extracellular adenosine triphosphate (ATP). P2RX2 is part of the P2X receptor family, comprising seven subtypes (P2X1-7) that mediate cellular responses to ATP, a key signaling molecule in physiological and pathological processes. Structurally, P2RX2 forms a trimeric channel with two transmembrane domains per subunit, facilitating cation flux (Na⁺, K⁺, Ca²⁺) upon ATP binding. It is widely expressed in the central nervous system, sensory neurons, cochlear hair cells, and epithelial tissues, playing roles in neurotransmission, pain perception, and auditory signaling.
P2RX2 antibodies are primarily used to study the receptor's expression, localization, and function in various tissues. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into P2RX2's involvement in diseases. For example, P2RX2 dysfunction is linked to noise-induced hearing loss, as ATP signaling in the cochlea helps regulate auditory sensitivity. Mutations in the P2RX2 gene are associated with progressive hearing impairment in humans. Additionally, P2RX2 is implicated in chronic pain pathways and neuroinflammatory conditions, making it a potential therapeutic target.
These antibodies are critical for elucidating receptor dynamics, ATP-mediated signaling mechanisms, and their pathophysiological relevance. Researchers rely on validated P2RX2 antibodies to explore its role in cellular communication, sensory processing, and disease models, advancing insights into purinergic signaling and related therapies.
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