| 纯度 | >85%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MAGEB10 |
| Uniprot No | Q96LZ2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-347aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMGSMPRGQKSKLRAREKRRQARGGLEDLID ALDILEEEEESPPSASACLKDVFQSSLDGASNNPHGLREAQSTSTSATAA SHTRHPEGVNDQMEERPICTQDLEATDSFP RGPVDEKVIILVHYLLYKYQMKEPITKADMLRNVTQMSKSQFPVILSRAS EHLELIFGLDLKEVEPNKHIYVLVNKLDLGCDAKLSDETGVPKTGLLMTV LGIIFTNGNCVAEEEVWKVFNTMGLYDGIEHFMFGEPRKLLTKDLVKENY LEYQQVPNSDPPRYQFLWGPRAHAETSKMKVLEFLAKVNDTAPSEFSNWY TEALQDEEERARARVAAKAR VSATAGARSKVKSSKSSQLQ |
| 预测分子量 | 41 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
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MAGEB10 (Melanoma-Associated Antigen Gene B10) is a member of the MAGE protein family, which is characterized by shared MAGE homology domains. These proteins are primarily expressed in germline cells and certain cancers but are typically silent in healthy somatic tissues. MAGEB10 belongs to the type I MAGE subfamily, known for their cancer-testis antigen (CTA) properties, making them potential targets for immunotherapy due to their tumor-specific expression.
The MAGEB10 gene is located on the X chromosome and encodes a protein implicated in regulating transcriptional processes, ubiquitination pathways, and epigenetic modifications. Studies suggest it may interact with E3 ubiquitin ligases or chromatin-remodeling complexes, influencing cell cycle progression, apoptosis, and differentiation. Its overexpression has been observed in various cancers, including melanoma, lung, and ovarian cancers, correlating with tumor aggressiveness, metastasis, and poor prognosis.
Recombinant MAGEB10 protein is produced using expression systems like *E. coli* or mammalian cells, often fused with tags (e.g., His-tag) for purification. It serves as a critical tool for studying protein-protein interactions, antibody development, and validating diagnostic or therapeutic strategies. Researchers also explore its role in immune evasion mechanisms, as CTAs like MAGEB10 may contribute to resistance against conventional therapies.
Despite its potential, challenges remain in understanding its precise molecular functions and post-translational modifications. Further research on recombinant MAGEB10 could advance cancer biomarker discovery and personalized immunotherapies, such as vaccines or CAR-T cells targeting MAGEB10-positive malignancies.
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