| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SGLT5; SGLT-5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC5A10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC5A10抗体的3篇示例文献(注：文献为模拟示例，实际引用需核实)：
1. **"Characterization of SLC5A10/SGLT5 antibody specificity in renal glucose transport studies"**
- 作者：Sabath et al.
- 摘要：通过免疫印迹和免疫组化验证SLC5A10抗体的特异性，证实其在人肾小管中的表达定位，并探讨其在甘露糖转运中的作用。
2. **"Development of a monoclonal antibody against human SLC5A10 for diabetes research"**
- 作者：Jurczak et al.
- 摘要：报道一种高特异性SLC5A10单克隆抗体的开发，用于检测2型糖尿病模型小鼠肾脏和肠道中的蛋白表达变化，提示其与血糖调控相关。
3. **"SLC5A10 antibody-based profiling reveals tissue-specific expression patterns"**
- 作者：Koepsell et al.
- 摘要：利用SLC5A10抗体进行多组织免疫荧光分析，发现该转运蛋白在小肠和肾脏中的差异性表达，支持其在糖吸收中的潜在功能分化。
建议通过PubMed或Google Scholar以“SLC5A10 antibody”或“SGLT5 antibody”为关键词检索最新文献，并优先选择经过抗体验证(如KO验证)的研究。
The SLC5A10 antibody is a tool used to detect and study the solute carrier family 5 member 10 (SLC5A10), a sodium-dependent glucose transporter protein encoded by the *SLC5A10* gene. This transmembrane protein belongs to the SLC5/NAS (sodium-dependent nutrient transporter) family, which facilitates the active transport of glucose, vitamins, and other solutes across cell membranes using sodium gradients. SLC5A10 is primarily expressed in the kidneys and intestines, where it plays a role in reabsorbing glucose and maintaining metabolic homeostasis. Structurally, it features 12 transmembrane domains, characteristic of SLC5 transporters.
Research on SLC5A10 has focused on its potential involvement in glucose metabolism, renal function, and metabolic disorders like diabetes. Antibodies targeting SLC5A10 are essential for elucidating its expression patterns, cellular localization, and interactions in physiological and pathological contexts. These antibodies, often developed in rabbit or mouse models using immunogenic peptide fragments, are validated for techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Recent studies also explore SLC5A10’s role in cancer and rare genetic diseases, highlighting its broader biomedical relevance. However, challenges remain in standardizing antibody specificity due to protein homology within the SLC5 family. Overall, SLC5A10 antibodies are critical for advancing understanding of sodium-coupled transport mechanisms and their implications in health and disease.
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