| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AZU-1; ECTACC |
| WB Predicted band size | 310 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TACC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TACC2抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *"TACC2 is required for spindle assembly and progression of mitosis in mammalian cells"*
**作者**: Gorjanacz M., et al.
**摘要**: 该研究利用TACC2特异性抗体，通过免疫荧光和Western blot分析，揭示了TACC2在有丝分裂纺锤体组装中的关键作用，并发现其缺失导致染色体排列异常和细胞周期停滞。
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2. **文献名称**: *"Interaction of TACC2 with HER2 and its potential role in breast cancer progression"*
**作者**: Lauffart B., et al.
**摘要**: 研究通过免疫共沉淀(Co-IP)和免疫组化技术，结合TACC2抗体，发现TACC2与HER2在乳腺癌细胞中相互作用，可能通过调控MAPK信号通路促进肿瘤侵袭性。
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3. **文献名称**: *"Structural and functional characterization of the TACC2 dimerization domain"*
**作者**: Sadek C.M., et al.
**摘要**: 该研究利用TACC2抗体进行免疫印迹和结构分析，解析了TACC2蛋白的二聚化结构域，并证明其卷曲螺旋区域对维持蛋白稳定性及与其他微管结合蛋白的相互作用至关重要。
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4. **文献名称**: *"TACC2 expression correlates with poor prognosis in ovarian cancer"*
**作者**: Miyake Y., et al.
**摘要**: 通过免疫组织化学(IHC)和高通量蛋白组学分析，结合TACC2抗体，研究发现TACC2在卵巢癌组织中高表达，并与患者生存率下降及化疗耐药性显著相关。
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这些文献均通过TACC2抗体在实验中对蛋白功能、相互作用或临床意义进行了探讨，涵盖基础机制到疾病关联研究。
The TACC2 (Transforming Acidic Coiled-Coil Containing Protein 2) antibody is a tool used to study the TACC2 protein, a member of the conserved TACC family involved in cellular processes such as mitotic spindle organization, transcriptional regulation, and microtubule dynamics. TACC2. encoded by the *TACC2* gene in humans, shares structural homology with TACC1 and TACC3. including a characteristic coiled-coil domain. However, its functional roles appear distinct, with studies linking it to cell cycle progression, differentiation, and cancer biology. TACC2 is expressed in multiple isoforms due to alternative splicing, contributing to tissue-specific functions in the brain, testes, and other organs. Dysregulation of TACC2 has been implicated in cancers, including breast and ovarian tumors, where it may act as an oncogene or tumor suppressor depending on context.
Antibodies targeting TACC2 enable researchers to detect its expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial TACC2 antibodies are typically raised against specific epitopes, often validated using knockout controls to confirm specificity. Challenges in TACC2 research include cross-reactivity with other TACC family members and isoform-specific detection, necessitating careful antibody validation. Current studies focus on elucidating TACC2's role in cancer progression, neuronal development, and its potential as a therapeutic target. Ongoing efforts aim to clarify its molecular mechanisms, particularly in chromatin remodeling complexes and centrosome amplification pathways.
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