关键信息
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基因名
PLBD2
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简介
The PLBD2 protein is a putative phospholipase that interacts with IGF2R, suggesting a potential role in insulin-like growth factor 2 receptor-related signaling pathways. Although the enzymatic activity and functional role of PLBD2 remain to be characterized in detail, its association with IGF2R suggests involvement in cell signaling related to growth and development. PLBD2 Protein, Human (HEK293, His) is the recombinant human-derived PLBD2 protein, expressed by HEK293 , with C-His labeled tag.
- 应用
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别名
Putative phospholipase B-like 2; p76; LAMA-like protein 2; PLBD2
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种属
Human
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q8NHP8-1
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表达区间
I42-D589
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氨基酸序列
IPAPGGRWARDGQVPPASRSRSVLLDVSAGQLLMVDGRHPDAVAWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEYEVGYCERLKSFLEANLEWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKFTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGSGSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFREGPWGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVRPRGCVLEWVRNIVANRLASDGATWADIFKRFNSGTYNNQWMIVDYKAFIPGGPSPGSRVLTILEQIPGMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLMRYNDFLHDPLSLCKACNPQPNGENAISARSDLNPANGSYPFQALRQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPPFQWSTSPFSGLLHMGQPDLWKFAPVKVSWD
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
80 & 45 & 32 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PLBD2 (phospholipase B domain-containing protein 2) has emerged as a protein of interest due to its potential roles in lipid metabolism and cellular signaling. This protein is primarily expressed in various tissues, suggesting its involvement in diverse biological processes. Research indicates that PLBD2 might contribute to membrane lipid remodeling and thus influence cell membrane properties, impacting cellular functions such as growth, differentiation, and apoptosis. Given its enzymatic activity related to phospholipid hydrolysis, PLBD2 has been implicated in the pathogenesis of several diseases, including inflammatory disorders and metabolic syndromes. Despite its potential significance, the detailed mechanisms through which PLBD2 operates remain poorly understood, necessitating further investigation. Recombinant PLBD2 protein studies provide a valuable tool for elucidating its structural and functional characteristics, enabling researchers to explore its enzymatic properties, substrate specificity, and regulatory mechanisms. Such studies could open novel therapeutic avenues targeting PLBD2-related pathways, making it a focal point for future research in both basic biology and clinical applications. Overall, by advancing our understanding of PLBD2, we aim to clarify its biological significance and therapeutic potential in various health conditions.
