| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RCN3; MCIP3; hRCN3; DSCR1L2 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human RCAN3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RCAN3抗体的3篇参考文献示例(内容为模拟生成，仅供参考)：
1. **文献名称**：*RCAN3 regulates mitochondrial function and protects against oxidative stress in cardiomyocytes*
**作者**：Li X, Wang Y, Zhang H
**摘要**：研究利用特异性RCAN3抗体，揭示了RCAN3通过调控线粒体动力学和ROS代谢在心肌细胞氧化应激中的保护作用，为心血管疾病治疗提供新靶点。
2. **文献名称**：*Development and validation of a high-affinity monoclonal antibody for RCAN3 protein quantification*
**作者**：Smith J, et al.
**摘要**：报道了一种新型RCAN3单克隆抗体的制备与验证，通过ELISA和免疫印迹证实其高特异性和敏感性，可用于临床样本中RCAN3表达的精准检测。
3. **文献名称**：*RCAN3 expression is downregulated in Alzheimer's disease brains: Evidence from immunohistochemical analysis*
**作者**：Garcia-Ruiz S, et al.
**摘要**：采用RCAN3多克隆抗体对阿尔茨海默病患者脑组织进行免疫组化分析，发现RCAN3表达显著降低，提示其可能参与tau蛋白异常磷酸化病理过程。
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**注**：以上文献为示例，实际引用时需通过PubMed、Google Scholar等平台以“RCAN3 antibody”或“RCAN3 function”为关键词检索真实论文，并核对作者及摘要信息。
RCAN3 (Regulator of Calcineurin 3) is a member of the RCAN family, which modulates the activity of calcineurin, a calcium-dependent phosphatase involved in critical cellular processes such as immune response, cardiac development, and synaptic plasticity. RCAN3. encoded by the *RCAN3* gene, acts as a feedback inhibitor of calcineurin signaling, helping to maintain cellular homeostasis by preventing excessive phosphatase activity. While less studied compared to other family members (e.g., RCAN1), emerging evidence suggests RCAN3 may play roles in neurodevelopment, stress responses, and calcium signaling regulation. Dysregulation of calcineurin pathways has been implicated in neurodegenerative diseases, cardiovascular disorders, and Down syndrome, highlighting the potential relevance of RCAN3 in these contexts.
RCAN3 antibodies are essential tools for investigating the protein’s expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study RCAN3 in tissues or cell lines. Researchers also employ these antibodies to explore RCAN3’s interaction with calcineurin and its regulatory mechanisms under physiological or pathological conditions. Commercially available RCAN3 antibodies are typically raised against specific epitopes, with validation across species (e.g., human, mouse). However, variability in antibody specificity and performance underscores the need for rigorous validation in experimental systems. Ongoing studies aim to clarify RCAN3’s distinct roles and its potential as a therapeutic target.
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