Rabbit Polyclonal CDX4 Antibody

The CDX4 antibody is a crucial tool in studying the CDX4 protein, a member of the caudal-related homeobox transcription factor family. CDX4 plays a pivotal role in embryonic development, particularly in regulating hematopoiesis, intestinal differentiation, and axial patterning. It shares structural homology with other CDX proteins (CDX1. CDX2), featuring a conserved DNA-binding homeodomain that mediates transcriptional regulation of target genes, including HOX genes. CDX4 is implicated in both normal physiological processes and diseases; dysregulation has been linked to hematologic malignancies like leukemia and colorectal cancer. Researchers use CDX4 antibodies primarily for detecting protein expression via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate CDX4's spatial-temporal expression patterns, interactions with signaling pathways (e.g., Wnt/β-catenin), and roles in cellular differentiation or oncogenesis. Commercial CDX4 antibodies are typically raised against specific epitopes, often in rabbit or mouse hosts, and validated for species reactivity (human, mouse, rat). Their applications span developmental biology, cancer research, and regenerative medicine, offering insights into CDX4's function as a potential biomarker or therapeutic target. Proper controls (e.g., knockout validation) are essential to ensure antibody specificity in experimental settings.