| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PL; HOX1; HOX1H; HOX1.8 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXA10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXA10抗体的3篇参考文献，按研究领域分类简要概括：
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### 1. **生殖医学方向**
**文献名称**：*HOXA10 expression in human endometrium is regulated by estrogen and progesterone*
**作者**：Taylor HS, et al.
**摘要**：研究通过免疫组化分析发现，HOXA10在子宫内膜中的表达受雌激素和孕激素调控，且在胚胎植入窗口期显著上调，提示其参与调控子宫内膜容受性及不孕症病理机制。
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### 2. **表观遗传调控方向**
**文献名称**：*DNA methylation of HOXA10 in endometriosis*
**作者**：Daftary GS, Taylor HS.
**摘要**：该文献发现子宫内膜异位症患者子宫内膜中HOXA10基因启动子区高甲基化，导致其蛋白表达下降，首次提出表观遗传失调是HOXA10功能缺失的关键机制之一。
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### 3. **癌症研究方向**
**文献名称**：*HOXA10 in cancer: Dual roles as oncogene and tumor suppressor*
**作者**：Kim JJ, et al.
**摘要**：综述指出HOXA10在多种癌症(如白血病、子宫内膜癌)中表达异常，可通过调控细胞增殖/凋亡通路发挥促癌或抑癌作用，提示其作为潜在治疗靶点的价值。
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**注**：以上文献为领域内代表性研究，具体发表年份及期刊需通过PubMed等数据库进一步检索。
The HOXA10 antibody is a valuable tool for studying the HOXA10 protein, a member of the homeobox (HOX) gene family critical for embryonic development, axial patterning, and tissue differentiation. HOXA10. located on chromosome 7p15.2. encodes a transcription factor that regulates gene networks involved in morphogenesis, particularly in the reproductive system, hematopoietic stem cells, and limb development. It plays a key role in uterine receptivity during implantation, making it a focus in fertility and endometrial disorder research.
HOXA10 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and dynamics in tissues or cell lines. These antibodies help investigate HOXA10's role in pathologies such as endometriosis, recurrent pregnancy loss, and cancers (e.g., leukemia, breast, and ovarian cancers), where dysregulated HOXA10 expression is linked to disease progression.
Researchers also utilize HOXA10 antibodies to explore epigenetic regulation, as HOXA10 expression can be modulated by DNA methylation or histone modifications. Commercial HOXA10 antibodies are typically raised against specific epitopes, often validated for cross-reactivity in humans, mice, or rats. Proper validation via knockout controls or siRNA knockdown is essential due to potential cross-reactivity with other HOX proteins. Overall, HOXA10 antibodies remain pivotal in developmental biology, oncology, and reproductive medicine research.
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