| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FNIPL; MAPO1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FNIP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3-4篇关于FNIP2抗体的代表性文献，按研究方向和内容概括整理：
1. **文献名称**：*FNIP2 regulates AMPK and mTORC1 signaling in skeletal muscle of mice*
**作者**：Park H, et al.
**摘要**：本研究利用FNIP2特异性抗体探究了FNIP2在骨骼肌能量代谢中的作用，发现其通过调控AMPK-mTORC1信号通路影响线粒体功能，为代谢疾病研究提供新靶点。
2. **文献名称**：*Interaction between folliculin and FNIP2 is critical for renal tumor suppression*
**作者**：Hasumi H, et al.
**摘要**：通过免疫共沉淀(使用FNIP2抗体)和功能实验，揭示FNIP2与卵泡素(folliculin)的相互作用在抑制肾癌发生中的关键作用，并证实其缺陷导致mTOR信号异常激活。
3. **文献名称**：*Proteomic analysis of FNIP2-deficient cells reveals dysregulation of lysosomal pathways*
**作者**：Chen J, et al.
**摘要**：利用FNIP2抗体进行蛋白质组学分析，发现FNIP2缺失导致溶酶体通路紊乱，提示其在细胞自噬和癌症进展中的潜在调控机制。
4. **文献名称**：*Development and validation of a monoclonal FNIP2 antibody for immunohistochemical applications*
**作者**：Li Y, et al.
**摘要**：本文描述了一种新型FNIP2单克隆抗体的开发与验证，成功应用于组织切片的免疫组化检测，并验证其在多种癌症样本中的表达差异。
注：以上文献信息为示例，实际文献需通过PubMed或Google Scholar检索确认。
The FNIP2 (Folliculin Interacting Protein 2) antibody is a research tool used to detect and study the FNIP2 protein, which plays a critical role in cellular metabolic regulation. FNIP2 interacts with folliculin (FLCN), a tumor suppressor protein linked to Birt-Hogg-Dubé (BHD) syndrome, a genetic disorder associated with kidney tumors, lung cysts, and skin lesions. Together, FNIP2 and FLCN form a complex that modulates the AMP-activated protein kinase (AMPK)-mTORC1 signaling axis, influencing energy sensing, cell growth, and autophagy. Dysregulation of this pathway is implicated in cancer, metabolic diseases, and renal pathologies.
FNIP2 antibodies are primarily utilized in Western blotting, immunoprecipitation, and immunohistochemistry to investigate protein expression, localization, and interactions in various tissues and disease models. Researchers employ these antibodies to explore FNIP2's role in cellular responses to nutrient stress, its involvement in tumorigenesis, and its potential as a therapeutic target. Specificity and validation of FNIP2 antibodies are crucial, as cross-reactivity with homologous proteins like FNIP1 may occur. Recent studies also highlight FNIP2's involvement in immune regulation and mitochondrial function, expanding its relevance in metabolic and oncological research.
×
