| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MAT, SAMS, MATA1, SAMS1 |
| WB Predicted band size | 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MAT1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAT1A抗体的3篇参考文献示例(内容基于领域内常见研究方向，建议通过学术数据库核对具体信息)：
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1. **文献名称**: "Downregulation of MAT1A in Hepatocellular Carcinoma and Its Clinical Implications"
**作者**: Lu SC, et al.
**摘要**: 研究通过免疫组化(使用MAT1A特异性抗体)分析肝细胞癌(HCC)组织中MAT1A蛋白表达，发现MAT1A表达显著降低，且与患者预后不良相关，提示其作为HCC潜在治疗靶点的可能性。
2. **文献名称**: "DNA Methylation Silences MAT1A Expression in Human Liver Cancer"
**作者**: Yang H, et al.
**摘要**: 探讨MAT1A基因启动子甲基化对其表达的调控，通过Western blot和免疫荧光(基于MAT1A抗体)证实甲基化导致蛋白表达沉默，并关联肝细胞癌进展中的代谢异常。
3. **文献名称**: "MAT1A Deficiency Alters Hepatic Methionine Metabolism in Mice"
**作者**: Mato JM, et al.
**摘要**: 利用MAT1A基因敲除小鼠模型，通过抗体检测肝脏组织中MAT1A蛋白缺失，揭示其缺失引发甲硫氨酸代谢紊乱及脂肪变性，为肝病机制研究提供依据。
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**注意**：以上文献信息为示例，实际引用时请通过PubMed、Web of Science等平台检索最新或特定研究，并核对作者、标题及摘要准确性。
MAT1A (Methionine Adenosyltransferase 1A) is a crucial enzyme encoded by the MAT1A gene, primarily expressed in the liver. It catalyzes the synthesis of S-adenosylmethionine (SAMe), the principal methyl donor in numerous biological processes, including methylation of DNA, proteins, and lipids. MAT1A plays a pivotal role in maintaining hepatic function, regulating oxidative stress, and influencing cell proliferation. Dysregulation of MAT1A is linked to liver diseases (e.g., cirrhosis, hepatocellular carcinoma), metabolic disorders, and certain cancers, underscoring its importance in cellular homeostasis.
MAT1A antibodies are immunological tools designed to detect and quantify MAT1A protein expression in research applications. These antibodies, often developed in rabbit or mouse hosts, are validated for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specificity is ensured through epitope mapping or knockout validation. Researchers use MAT1A antibodies to investigate its expression patterns in disease models, study SAMe-related metabolic pathways, or explore therapeutic targets. Commercial MAT1A antibodies typically include detailed datasheets outlining cross-reactivity, recommended dilutions, and storage conditions. Reliable MAT1A antibodies are critical for advancing studies on liver pathophysiology, epigenetics, and cancer metabolism.
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