Rabbit Polyclonal TGIF2LX Antibody

The TGIF2LX antibody targets the protein product of the *TGIF2LX* gene, a member of the TALE/homeodomain superfamily. TGIF2LX (TGIF2-like X-linked) is a paralog of TGIF2. located on the X chromosome, and shares homology with TGIF1 and TGIF2. which are transcriptional corepressors interacting with SMAD proteins to modulate TGF-β signaling. While TGIF2LX's exact biological role remains less characterized, it is implicated in transcriptional regulation, embryonic development, and cell differentiation. Dysregulation of TGIF family proteins is linked to cancers and developmental disorders, with TGIF2LX potentially contributing to X-linked pathologies. The TGIF2LX antibody is primarily used in research to detect and study the protein's expression, localization, and interactions in cellular and tissue contexts. It aids in elucidating TGIF2LX's role in gene regulatory networks, epigenetic modifications, and disease mechanisms, particularly in cancers like hepatocellular carcinoma or ovarian cancer. Commercial antibodies are typically validated for techniques such as Western blotting, immunohistochemistry, and immunofluorescence. However, cross-reactivity with related TGIF family members requires careful experimental controls. Ongoing studies aim to clarify its tissue-specific functions and therapeutic relevance.