| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ANX6, CBP68 |
| WB Predicted band size | 76 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ANXA6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANXA6抗体的3篇文献示例(内容基于公开研究概括，非真实文献)：
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1. **文献名称**: *ANXA6 modulates EGFR signaling in triple-negative breast cancer*
**作者**: Smith J, et al.
**摘要**: 研究利用ANXA6抗体通过免疫印迹和免疫荧光技术，揭示ANXA6通过调控EGFR膜定位影响乳腺癌细胞信号传导，为靶向治疗提供新方向。
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2. **文献名称**: *ANXA6 deficiency exacerbates cardiac hypertrophy via calcium handling dysregulation*
**作者**: Wang L, et al.
**摘要**: 通过ANXA6抗体进行组织染色和蛋白分析，发现ANXA6缺失导致心肌细胞钙稳态失衡，加剧小鼠模型中心脏肥厚病理进程。
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3. **文献名称**: *ANXA6 as a biomarker for diabetic nephropathy progression*
**作者**: Gupta R, et al.
**摘要**: 采用ANXA6抗体检测肾组织样本，证实ANXA6在糖尿病肾病患者的肾小球中高表达，其水平与纤维化程度正相关，提示其作为疾病进展标志物的潜力。
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如需具体文献，建议通过PubMed或Web of Science以“ANXA6 antibody”为关键词检索，并筛选实验方法学中包含该抗体的研究(如Western blot、IHC等)。
ANXA6 (Annexin A6) is a member of the annexin protein family, characterized by calcium-dependent membrane-binding properties and involvement in diverse cellular processes such as membrane organization, signal transduction, and intracellular trafficking. This 67-72 kDa protein contains eight annexin repeats, distinguishing it from other annexins that typically have four. ANXA6 is implicated in regulating cholesterol homeostasis, endocytosis, and exocytosis, with roles in pathologies like cancer, diabetes, and cardiovascular diseases. Its expression varies across tissues, showing high levels in the liver, adrenal glands, and endothelial cells.
ANXA6 antibodies are essential tools for studying the protein’s localization, interactions, and expression patterns. They are widely used in techniques including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers employ these antibodies to explore ANXA6’s dual role in cancer—acting as both a tumor suppressor and promoter depending on context—and its involvement in membrane repair mechanisms or viral entry pathways. Commercially available ANXA6 antibodies are raised in various hosts (e.g., rabbit, mouse) and validated for specificity using knockout cell lines or siRNA knockdown. Proper validation remains critical due to potential cross-reactivity with other annexins. Recent studies also highlight ANXA6 as a biomarker candidate, driving demand for reliable antibodies in diagnostic and therapeutic research.
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