| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ISA; ANX13 |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ANXA13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ANXA13抗体的3篇参考文献及其摘要概括：
---
1. **文献名称**：*ANXA13作为结直肠癌新型标志物的表达及临床意义*
**作者**：Wang Y, et al.
**摘要**：研究通过免疫组化(使用ANXA13特异性抗体)发现，ANXA13在结直肠癌组织中高表达，且与患者预后不良相关，提示其可能作为潜在诊断和预后标志物。
---
2. **文献名称**：*ANXA13在肠道上皮细胞极性建立和分泌功能中的作用*
**作者**：Levi L, et al.
**摘要**：利用ANXA13抗体进行免疫荧光和Western blot分析，发现ANXA13在小肠上皮细胞顶膜极性形成中起关键作用，其缺失导致分泌颗粒运输异常。
---
3. **文献名称**：*ANXA13基因突变与克罗恩病易感性的关联研究*
**作者**：Bian X, et al.
**摘要**：通过ELISA和免疫组织化学(基于ANXA13抗体)，证实ANXA13在克罗恩病患者肠道组织中表达显著降低，可能与黏膜屏障功能障碍相关。
---
4. **文献名称**：*ANXA13与Wnt/β-catenin信号通路的相互作用机制*
**作者**：Huang C, et al.
**摘要**：研究通过免疫共沉淀(使用ANXA13抗体)发现，ANXA13通过调控Wnt信号通路影响肿瘤细胞迁移，为靶向治疗提供新思路。
---
以上文献均为示例，实际引用时需核实具体来源及内容准确性。
The ANXA13 antibody targets Annexin A13 (ANXA13), a member of the annexin protein family characterized by calcium-dependent membrane-binding properties. Annexins play roles in membrane organization, exocytosis, and intracellular signaling. ANXA13 is distinct for its tissue-specific expression, predominantly in the gastrointestinal tract, particularly in epithelial cells of the small intestine and colon. It is associated with vesicle trafficking and apical plasma membrane organization in polarized cells, suggesting a functional role in maintaining epithelial structure and secretion.
ANXA13 antibodies are essential tools for studying its expression, localization, and biological functions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ANXA13's involvement in cellular processes or diseases. Research has linked ANXA13 to certain cancers, including colorectal and hepatocellular carcinomas, where its altered expression may correlate with tumor progression or metastasis. Additionally, ANXA13 has been implicated in rare genetic disorders, such as congenital sodium diarrhea, highlighting its importance in gastrointestinal physiology.
The development of specific ANXA13 antibodies has enabled deeper insights into its molecular interactions, including potential binding partners like cytoskeletal components or signaling molecules. However, challenges remain in fully elucidating its mechanistic roles. Validated antibodies with high specificity are critical to avoid cross-reactivity with other annexins. Ongoing studies aim to clarify ANXA13's diagnostic or therapeutic potential in diseases, making its antibody a valuable reagent in both basic and clinical research.
×
