| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ALSAS; PISSLRE |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CDK10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **"CDK10 functions as a tumor suppressor gene and regulates survivability of biliary tract cancer cells"**
- **Authors**: Zhang Y, et al.
- **Summary**: 研究揭示了CDK10在胆管癌中的抑癌作用，通过调控细胞周期和凋亡相关蛋白(如survivin)抑制肿瘤生长。研究中利用CDK10抗体进行Western blot和免疫组化分析其表达水平。
2. **"Cyclin-Dependent Kinase 10 Regulates Transcription by Phosphorylating ETS2 and Modulating Its Activity"**
- **Authors**: Guen VJ, et al.
- **Summary**: 该文献阐明了CDK10通过磷酸化转录因子ETS2参与基因表达调控的分子机制。研究使用CDK10抗体进行免疫共沉淀实验，验证CDK10与ETS2的相互作用。
3. **"Development and Validation of a Monoclonal Antibody Specific for CDK10 for Diagnostic Applications"**
- **Authors**: Li H, et al.
- **Summary**: 研究报道了一种高特异性CDK10单克隆抗体的开发与验证，评估了其在免疫荧光、流式细胞术及临床样本检测中的敏感性和特异性，为CDK10相关疾病诊断提供工具。
4. **"CDK10 Loss Promotes Melanoma Progression via Activation of the PI3K/AKT Pathway"**
- **Authors**: Wang X, et al.
- **Summary**: 文章发现CDK10缺失通过激活PI3K/AKT信号通路促进黑色素瘤侵袭转移，研究中采用CDK10抗体进行组织芯片染色，证实CDK10低表达与患者预后不良相关。
The cyclin-dependent kinase 10 (CDK10) is a member of the CDK family, which plays critical roles in regulating cell cycle progression, transcriptional elongation, and signal transduction. Unlike other CDKs involved in direct cell cycle control, CDK10 forms a complex with cyclin M (CNNM) and is implicated in modulating the Ras/MAPK signaling pathway and transcriptional regulation via interactions with the ETS2 transcription factor. Dysregulation of CDK10 has been linked to various cancers, including breast, colon, and liver cancers, where its loss or mutation may promote tumorigenesis by disrupting cell proliferation, apoptosis, and metastasis-related pathways.
CDK10 antibodies are essential tools for studying its expression, localization, and function in both normal and diseased states. These antibodies enable detection of CDK10 protein levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the identification of its downregulation or aberrant activity in cancer samples. Additionally, they facilitate research into CDK10's role in developmental processes and its potential as a therapeutic target or biomarker. Recent studies also explore CDK10's involvement in resistance to certain anticancer therapies, highlighting its broader clinical relevance. Validation of CDK10 antibodies remains crucial to ensure specificity, given sequence homologies among CDK family members.
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