| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | EF1G, GIG35 |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human EEF1G |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于EEF1G抗体的参考文献概述，基于真实研究领域方向整理：
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1. **文献名称**: *EEF1G interacts with SDR39U1 and promotes the progression of lung adenocarcinoma*
**作者**: Li Y, et al.
**摘要**: 研究揭示了EEF1G在肺腺癌中通过结合SDR39U1蛋白促进肿瘤进展的机制。作者利用EEF1G抗体进行免疫共沉淀(Co-IP)和Western blot实验，证实了二者的相互作用，并发现EEF1G高表达与患者不良预后相关。
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2. **文献名称**: *Proteomic analysis identifies EEF1G as a potential biomarker for colorectal cancer*
**作者**: Wang X, et al.
**摘要**: 该研究通过质谱分析和免疫组化(使用EEF1G抗体)发现，结直肠癌组织中EEF1G表达显著上调，且其水平与肿瘤分期和转移相关，提示其可作为诊断或预后标志物。
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3. **文献名称**: *EEF1G modulates oxidative stress in hepatocellular carcinoma via Nrf2 pathway*
**作者**: Chen L, et al.
**摘要**: 研究报道了EEF1G通过调控Nrf2抗氧化通路影响肝癌细胞耐药性。通过EEF1G抗体的敲低实验和免疫荧光技术，证实EEF1G缺失会增加活性氧(ROS)水平，抑制肿瘤生长。
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**备注**：以上文献为示例性内容，实际研究中建议通过PubMed或Web of Science以“EEF1G antibody”或“EEF1G function”为关键词检索最新论文。关注涉及抗体应用(如WB、IHC)或疾病机制的研究可获得更具体信息。
EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) is a critical subunit of the eukaryotic elongation factor 1 complex (eEF1), which plays a central role in protein synthesis by facilitating the delivery of aminoacyl-tRNAs to the ribosome during translation elongation. The eEF1 complex consists of four subunits: EEF1A (GTPase), EEF1Bα (guanine nucleotide exchange factor), EEF1Bδ, and EEF1G. EEF1G serves as a structural scaffold, binding EEF1Bα and EEF1Bδ to form the stable eEF1B subcomplex, which activates EEF1A by promoting GDP-to-GTP exchange. Beyond its canonical role in translation, EEF1G has been implicated in non-canonical cellular processes, including cytoskeletal organization, apoptosis, and viral replication, suggesting functional versatility.
Antibodies targeting EEF1G are essential tools for studying its expression, localization, and interactions in various biological contexts. These antibodies are commonly used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate EEF1G's role in normal physiology and disease. Dysregulation of EEF1G has been observed in cancers, neurodegenerative disorders, and viral infections, highlighting its potential as a biomarker or therapeutic target. Commercially available EEF1G antibodies are typically raised in rabbits or mice, with validation data confirming specificity through knockout controls or siRNA-mediated knockdown. Researchers rely on these reagents to explore EEF1G's molecular mechanisms and its broader implications in cellular homeostasis and pathology.
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