WB | 1/500-1/2000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/100-1/300 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
Aliases | FKHL18; FREAC10 |
WB Predicted band size | 35 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Fusion protein of human FOXS1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOXS1抗体的3篇示例参考文献(注:以下为虚构示例,实际文献请通过PubMed或Google Scholar查询):
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1. **文献名称**:*FOXS1 regulates neural differentiation through Notch signaling*
**作者**:Smith A, et al.
**摘要**:本研究利用兔源FOXS1多克隆抗体,通过Western blot和免疫荧光技术,发现FOXS1通过抑制Notch通路调控神经干细胞分化,提示其在神经发育中的关键作用。
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2. **文献名称**:*FOXS1 as a biomarker in prostate cancer progression*
**作者**:Johnson B, et al.
**摘要**:通过小鼠单克隆FOXS1抗体进行免疫组化分析,揭示FOXS1在前列腺癌转移组织中高表达,与患者预后不良显著相关,可能成为新型治疗靶点。
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3. **文献名称**:*Development of a monoclonal antibody for FOXS1 detection*
**作者**:Lee C, et al.
**摘要**:本研究成功开发并验证了一种高特异性FOXS1单克隆抗体,适用于ELISA和冰冻切片染色,为FOXS1蛋白的功能研究提供了可靠工具。
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**建议**:实际文献需在学术数据库(如PubMed)中检索关键词“FOXS1 antibody”或“FOXS1 immunohistochemistry”,并筛选近5年研究以获取最新进展。
FOXS1 (Forkhead Box S1) is a member of the forkhead box (FOX) family of transcription factors, characterized by a conserved DNA-binding domain known as the forkhead or winged-helix domain. FOX proteins play critical roles in regulating gene expression during development, differentiation, and cellular homeostasis. FOXS1. though less well-characterized compared to other FOX family members, is implicated in tissue-specific regulatory processes, particularly in mesenchymal and endothelial cells. Studies suggest its involvement in embryonic development, angiogenesis, and tissue repair. Its expression has been detected in various organs, including the kidney, lung, and heart, though its precise biological functions remain under investigation.
FOXS1 antibodies are essential tools for studying the protein's expression, localization, and role in cellular mechanisms. These antibodies enable detection of FOXS1 in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the exploration of its tissue distribution and regulation. Research has linked FOXS1 to pathological conditions, including fibrosis and cancer, where aberrant expression may influence disease progression. For instance, FOXS1 overexpression has been observed in certain tumors, suggesting potential roles in tumorigenesis or metastasis. However, its context-dependent functions require further validation.
Commercially available FOXS1 antibodies vary in species reactivity (e.g., human, mouse, rat) and applications. Validation via knockout controls or siRNA knockdown is recommended to ensure specificity. Ongoing research aims to clarify FOXS1's molecular interactions and therapeutic potential, positioning it as a target for understanding developmental biology and disease mechanisms.
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