| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | p62, IMP2, IMP-2, VICKZ2 |
| WB Predicted band size | 66 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IGF2BP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与IGF2BP2抗体相关的参考文献，内容基于公开研究整理：
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1. **文献名称**：*IGF2BP2 modulates colorectal cancer progression via mRNA stability regulation*
**作者**：Huang X, et al.
**摘要**：该研究利用IGF2BP2特异性抗体进行免疫组化和Western blot实验，发现IGF2BP2通过稳定致癌基因mRNA(如MYC)促进结直肠癌细胞增殖和转移。
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2. **文献名称**：*The role of IGF2BP2 in pancreatic cancer stemness and chemoresistance*
**作者**：Bell JL, et al.
**摘要**：通过免疫荧光和免疫共沉淀技术结合IGF2BP2抗体，揭示了该蛋白通过调控干细胞相关基因(如OCT4)的RNA稳定性，增强胰腺癌干性和化疗耐药性。
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3. **文献名称**：*IGF2BP2 recognition of N6-methyladenosine-modified RNAs in cancer progression*
**作者**：Müller S, et al.
**摘要**：研究使用IGF2BP2抗体进行RNA-蛋白结合实验(RIP-seq)，阐明其通过识别m6A修饰的RNA分子(如CCND1)调控细胞周期和肿瘤生长。
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4. **文献名称**：*Targeting IGF2BP2 as a therapeutic strategy in triple-negative breast cancer*
**作者**：Dai N, et al.
**摘要**：通过shRNA敲低和IGF2BP2抗体功能抑制实验，证明靶向该蛋白可降低肿瘤侵袭性，并提示其作为三阴性乳腺癌治疗靶点的潜力。
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*注：以上文献信息为示例性质，实际引用需核对真实出版物。建议通过PubMed或Web of Science以“IGF2BP2 antibody”和具体研究领域(如癌症类型)为关键词检索最新文章。*
The insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a member of the conserved RNA-binding protein family, primarily involved in post-transcriptional regulation of gene expression. It binds to target mRNAs through its KH domains, influencing stability, localization, and translation. IGF2BP2 is crucial in embryonic development, cell proliferation, and metabolism, with strong associations to diseases like cancer, diabetes, and neurological disorders. In cancer, it acts as an oncofetal protein, often overexpressed in malignancies such as glioblastoma, pancreatic, and lung cancers, where it promotes tumor progression by stabilizing oncogenic mRNAs (e.g., MYC, IGF2). Conversely, it may suppress metastasis in certain contexts, highlighting its context-dependent roles.
IGF2BP2 antibodies are essential tools for studying its expression, subcellular localization, and interactions in both physiological and pathological states. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has linked IGF2BP2 to insulin signaling and type 2 diabetes via genetic variants (e.g., rs4402960), emphasizing its metabolic relevance. Commercially available antibodies are typically validated for specificity against human, mouse, or rat samples, enabling cross-species studies. Their application extends to diagnostic potential, as IGF2BP2 expression patterns may serve as biomarkers for disease prognosis or therapeutic targeting.
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